ArticleThe journal of pain2022
Trends in Prescriptions for Non-opioid Pain Medications Among U.S. Adults With Moderate or Severe Pain, 2014-2018.
Article in The journal of pain, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 37 citations in OpenAlex.
- Shifting From Opioids to Simple Analgesics for Emergency Care of Patients With Low Back Pain: A Secondary Analysis of the SHAPED Cluster Randomized Trial.JAMA health forum · 2024Trial
- Article
- Prevalence and Correlates of Reporting a Gabapentin Prescription for Pain Among People Who Use Opioids: A Longitudinal Community-Recruited Study.Drug and alcohol review · 2026Article
- Article
- Mediation of chronic pain and disability on opioid use disorder risk by pain management practices among adult Medicaid patients, 2016-2019.American journal of epidemiology · 2026Article
- The impact of opioid prescribing guidelines on opioid dispensation: A systematic review and meta-analysis.Canadian journal of pain = Revue canadienne de la douleur · 2026Review
- Opioid dose, duration, and risk of use disorder in Medicaid patients with musculoskeletal pain.Pain medicine (Malden, Mass.) · 2026Article
- Do patients with migraine and obesity receive different treatments? Insights from real-world data.Headache · 2026Article
- Trends in Nonsurgical Interventions and Analgesic Medications for Low Back Pain: A Large Claims Database Study in Japan.Pain practice : the official journal of World Institute of Pain · 2025Article
- Regional and Temporal Variation in Receipt of Gabapentinoid and SSRI/SNRI Therapy Among Older Cancer Survivors in the United States.Current oncology (Toronto, Ont.) · 2025Article
- Association Between Gabapentinoid Use and Changes in Claims-Based Frailty Among Long-Term Opioid Users.Drugs & aging · 2025Article
- Trends in Drug Claims for Non-Specific Low Back Pain in Québec, 1997 to 2018.Musculoskeletal care · 2025Article
- Reconfiguring Pain Interpretation Within a Social Model of Health Using a Simplified Version of Wilber's All Quadrant All Levels Framework: An Integral Vision.Behavioral sciences (Basel, Switzerland) · 2025Article
- The 2016 CDC Opioid Guideline and Analgesic Prescribing Patterns in Older Adults With Cancer.JAMA network open · 2025Article
- Trends in Celecoxib Prescribing: A Single Institution 16-Month Review.Journal of clinical medicine · 2025Article
- The Combined Relationship of Prescription Drug Monitoring Program Enactment and Medical Cannabis Laws with Chronic Pain-Related Healthcare Visits.Journal of general internal medicine · 2025Article
- An integral vision of pain and its persistence: a whole-person, whole-system, salutogenic perspective.Frontiers in pain research (Lausanne, Switzerland) · 2025Article
- Trends in Opioid Use Disorder in the Veterans Health Administration, 2005-2022.JAMA network open · 2024Article
- Characteristics of US Medicare Beneficiaries with Chronic Cough vs. Non-Chronic Cough: 2011-2018.Journal of clinical medicine · 2024Article
- Patterns of gabapentinoid use among long-term opioid users.Preventive medicine · 2024Article
Corrections and comments
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Authors and funding
11 authors at 6 institutions in 1 country.
Funding
Abstract
As opioid prescribing has declined, it is unclear how the landscape of prescription pain treatment across the U.S. has changed. We used nationally-representative data from the Medical Expenditure Health Survey, 2014 to 2018 to examine trends in prescriptions for opioid and non-opioid pain medications, including acetaminophen, non-steroidal anti-inflammatory drugs, gabapentinoids, and antidepressants among U.S. adults with self-reported pain. Overall, from 2014 to 2018, the percentage of participants receiving a prescription for opioids declined, (38.8% vs 32.8%), remained stable for non-steroidal anti-inflammatory drugs (26.8% vs 27.7%), and increased for acetaminophen (1.6% vs 2.3%), antidepressants (9.6% vs 12.0%) and gabapentinoids (13.2% vs 19.0%). In this period, the adjusted odds of receiving an opioid prescription decreased (aOR = .93, 95% CI = .90-.96), while the adjusted odds of receiving antidepressant, gabapentinoid and acetaminophen prescriptions increased (antidepressants: aOR = 1.08, 95% CI = 1.03-1.13 gabapentinoids: aOR = 1.11, 95% CI = 1.06-1.17; acetaminophen: aOR = 1.10, 95% CI: 1.02-1.20). Secondary analyses stratifiying within the 2014 to 2016 and 2016 to 2018 periods revealed particular increases in prescriptions for gabapentinoids (aOR = 1.13, 95% CI = 1.05-1.21) and antidepressants (aOR = 1.23, 95% CI = 1.12-1.35) since 2016. PERSPECTIVE: These data demonstrate that physicians are increasingly turning to CDC-recommended non-opioid medications for pain management, particularly antidepressants and gabapentinoids. However, evidence for these medications' efficacy in treating numerous common pain conditions, including low back pain, remains limited.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.