Evidence map›Paper›PMID 35143832›Full record

ReviewExperimental neurology2022

Finely-tuned gamma oscillations: Spectral characteristics and links to dyskinesia.

C Wiest, F Torrecillos, G Tinkhauser, A Pogosyan, F Morgante, E A Pereira, H Tan

Open access · hybridAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Experimental neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 62 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Article
  4. The potential of utilizing Local Field Potential (LFP) in diagnosis and management of Parkinsonism's hallmark symptoms: a comprehensive review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Review
  5. Article
  6. Article
  7. Article
  8. Layer 6 Corticothalamic Neurons Induce High Gamma Oscillations Through Cortico-cortical and Cortico-thalamo-cortical Pathways.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  9. Article
  10. Article
  11. Finely Tuned γ Tracks Medication Cycles in Parkinson's Disease: An Ambulatory Brain-Sense Study.Movement disorders : official journal of the Movement Disorder Society · 2025
    Article
  12. Review
  13. Article
  14. Review
  15. Article
  16. Review
  17. Article
  18. Closed-Loop Brain Stimulation.Biological psychiatry · 2024
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

C WiestMedical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
F TorrecillosMedical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
G TinkhauserDepartment of Neurology, Bern University Hospital and University of Bern, Bern, Switzerland.
A PogosyanMedical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK.
F MorganteNeurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK; Department of Clinical and Experimental Medicine, University of Messina, Messina, Italy.
E A PereiraNeurosciences Research Centre, Molecular and Clinical Sciences Institute, St. George's, University of London, London, UK.
H TanMedical Research Council Brain Network Dynamics Unit, University of Oxford, Oxford, UK; Nuffield Department of Clinical Neurosciences, John Radcliffe Hospital, University of Oxford, Oxford, UK. Electronic address: huiling.tan@ndcn.ox.ac.uk.
St George's, University of London · GBJohn Radcliffe Hospital · GBMedical Research Council · GBMRC Brain Network Dynamics Unit · GBUniversity of Bern · CHUniversity of Oxford · GB

Funding

Department of HealthMedical Research Council MC_UU_00003/2Medical Research Council MR/P012272/1Medical Research Council MR/V00655X/1
6 · The paper itself

Abstract

Gamma oscillations comprise a loosely defined, heterogeneous group of functionally different activities between 30 and 100 Hz in the cortical and subcortical local field potential (LFP) of the motor network. Two distinct patterns seem to emerge which are easily conflated: Finely-tuned gamma (FTG) oscillations - a narrowband activity with peaks between 60 and 90 Hz - have been observed in multiple movement disorders and are induced by dopaminergic medication or deep brain stimulation (DBS). FTG has been linked with levodopa or DBS-induced dyskinesias, which makes it a putative biomarker for adaptive DBS. On the other hand, gamma activity can also present as a broad phenomenon (30-100 Hz) in the context of motor activation and dynamic processing. Here, we contrast FTG, either levodopa-induced or DBS-induced, from movement-related broadband gamma synchronisation and further elaborate on the functional role of FTG and its potential implications for adaptive DBS. Given the unclear distinction of FTG and broad gamma in literature, we appeal for more careful separation of the two. To better characterise cortical and subcortical FTG as biomarkers for dyskinesia, their sensitivity and specificity need to be investigated in a large clinical trial.

Indexed as

Deep Brain StimulationDyskinesiasLevodopaHumansLevodopaAdaptive deep brain stimulationDyskinesiaFinely-tuned gammaLocal field potentialsMovement-related gamma synchronisationNarrowband gammaOscillationsParkinson's disease

Identifiers

PMID35143832
PMCPMC7612436
OpenAlexW4210328296

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.