Evidence map›Paper›PMID 35143733›Full record

ArticlePerfusion2023

Comparison between Del Nido and conventional blood cardioplegia in pediatric open-heart surgery.

Alejandro A Floh, Shubhadeep Das, Maruti Haranal, Peter C Laussen, Lynn Crawford-Lean, Chun-Po S Fan, Luc L Mertens, Kyle Runeckles, Osami Honjo

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Perfusion, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.4field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

Alejandro A FlohDepartment of Critical Care Medicine, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.ORCID 0000-0001-5079-5305
Shubhadeep DasDepartment of Critical Care Medicine, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.ORCID 0000-0003-1996-2800
Maruti HaranalDivision of Cardiovascular Surgery, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.
Peter C LaussenDepartment of Critical Care Medicine, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.
Lynn Crawford-LeanPerfusion Services, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.
Chun-Po S FanCardiovascular Data Management Centre, 7938University of Toronto, Toronto, ON, Canada.
Luc L MertensLabatt Family Heart Centre, Division of Pediatric Cardiology, Department of Pediatrics, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.
Kyle RunecklesCardiovascular Data Management Centre, 7938University of Toronto, Toronto, ON, Canada.
Osami HonjoDivision of Cardiovascular Surgery, Hospital for Sick Children, 7979University of Toronto, Toronto, ON, Canada.
University of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDel Nido cardioplegia (DNc) was designed for superior myocardial protection during cardiopulmonary bypass (CPB). We conducted a retrospective review to explore if DNc was associated with increase in systemic ventricle dysfunction (sVD) following pediatric CPB. METHODS AND

resultsThis single-center, retrospective study included 1534 patients undergoing CPB between 2013 and 2016, 997 prior to center-wide conversion to DNc and 537 following. The primary outcome was new postoperative ≥moderate sVD by echocardiogram. Secondary outcomes included sVD of any severity and right ventricular dysfunction. Data was evaluated by interrupted time-series analysis. Groups had similar cardiac diagnoses and surgical complexity. Del Nido cardioplegia was associated with longer median (IQR) CPB [117 (84-158) vs 108 (81-154),

conclusionsUse of DNc was not associated with increased in reported sVD, and provided similar myocardical protection to the systemic ventricle compared to conventional cardioplegia but may possibly impact right ventricular function. Studies evaluating quantitative systolic and diastolic function are needed.

Indexed as

Cardiac Surgical ProceduresVentricular Dysfunction, RightCardioplegic SolutionsChildHeart Arrest, InducedHumansInfantInfant, NewbornRetrospective StudiesCardioplegic Solutionscardiac surgerycardiopulmonary bypassDel Nido cardioplegiapediatricventricular function

Identifiers

PMID35143733
PMCPMC9932617
OpenAlexW4211070449

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.