ArticlePLoS genetics2022
Multi-insecticide resistant malaria vectors in the field remain susceptible to malathion, despite the presence of Ace1 point mutations.
Article in PLoS genetics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 48 citations in OpenAlex.
- A multi-omic meta-analysis reveals novel mechanisms of insecticide resistance in malaria vectors.Communications biology · 2025Pooled it
- Sublethal effects of insecticides on the reproduction traits of insecticide-resistant Anopheles gambiae sensu lato mosquitoes from Tiassalé, Côte d'Ivoire.Parasites & vectors · 2026Article
- Anopheles coluzzii from Sakassou, Central Côte d'Ivoire show aggravated resistance to pyrethroids and organophosphate but are fully susceptible to clothianidin.Parasites & vectors · 2026Article
- Development of a multiplex SNaPshot assay for simultaneous detection of multiple insecticide-resistance mutations in Anopheles sinensis.Parasites & vectors · 2026Article
- Pyrethroids and organophosphate resistance in Aedes aegypti (Diptera: Culicidae) and their underlying mechanisms.Parasites & vectors · 2026Article
- Spatial Heterogeneity ofJournal of parasitology research · 2026Review
- Predictive chemoproteomics and functional validation reveal Coeae6g-mediated insecticide cross-resistance in the malaria vector Anopheles gambiae.Nature communications · 2025Article
- Characterization and abundance of malaria vectors in Sakassou, Central Côte d'Ivoire.Malaria journal · 2025Article
- Susceptibility profile of Anopheles and target site resistance mechanism against organophosphates in Cameroon.PloS one · 2025Article
- Efficacy of Pirikool® 300 CS used for indoor residual spraying on three different substrates in semi-field experimental conditions.Malaria journal · 2024Article
- Article
- The impact of agrochemical pollutant mixtures on the selection of insecticide resistance in the malaria vector Anopheles gambiae: insights from experimental evolution and transcriptomics.Malaria journal · 2024Article
- Level of involvement of four selected cytochrome P450s (CYPs) in pyrethroid-resistantCurrent research in parasitology & vector-borne diseases · 2024Article
- Relationship between insecticide resistance profiles in Anopheles gambiae sensu lato and agricultural practices in Côte d'Ivoire.Parasites & vectors · 2023Article
- Species composition and insecticide resistance in malaria vectors in Ellibou, southern Côte d'Ivoire and first finding of Anopheles arabiensis in Côte d'Ivoire.Malaria journal · 2023Article
- Small-scale field evaluation of PermaNetMalaria journal · 2023Article
- Phenotypic resistance to pyrethroid associated to metabolic mechanism inWellcome open research · 2023Article
- High Levels of Admixture inInsects · 2022Article
- Bendiocarb and Malathion Resistance in Two Major Malaria Vector Populations in Cameroon Is Associated with High Frequency of the G119S Mutation (Ace-1) and Overexpression of Detoxification Genes.Pathogens (Basel, Switzerland) · 2022Article
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Authors and funding
11 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Insecticide resistance in Anopheles mosquitoes is seriously threatening the success of insecticide-based malaria vector control. Surveillance of insecticide resistance in mosquito populations and identifying the underlying mechanisms enables optimisation of vector control strategies. Here, we investigated the molecular mechanisms of insecticide resistance in three Anopheles coluzzii field populations from southern Côte d'Ivoire, including Agboville, Dabou and Tiassalé. All three populations were resistant to bendiocarb, deltamethrin and DDT, but not or only very weakly resistant to malathion. The absence of malathion resistance is an unexpected result because we found the acetylcholinesterase mutation Ace1-G280S at high frequencies, which would typically confer cross-resistance to carbamates and organophosphates, including malathion. Notably, Tiassalé was the most susceptible population to malathion while being the most resistant one to the pyrethroid deltamethrin. The resistance ratio to deltamethrin between Tiassalé and the laboratory reference colony was 1,800 fold. By sequencing the transcriptome of individual mosquitoes, we found numerous cytochrome P450-dependent monooxygenases - including CYP6M2, CYP6P2, CYP6P3, CYP6P4 and CYP6P5 - overexpressed in all three field populations. This could be an indication for negative cross-resistance caused by overexpression of pyrethroid-detoxifying cytochrome P450s that may activate pro-insecticides, thereby increasing malathion susceptibility. In addition to the P450s, we found several overexpressed carboxylesterases, glutathione S-transferases and other candidates putatively involved in insecticide resistance.
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