Evidence map›Paper›PMID 35143424›Full record

ArticleChinese medical journal2022

Cancer statistics in China and United States, 2022: profiles, trends, and determinants.

Changfa Xia, Xuesi Dong, He Li, Maomao Cao, Dianqin Sun, Siyi He, Fan Yang, Xinxin Yan, Shaoli Zhang, Ni Li and 1 more

16 registry-linked trialsAbstract read
In one paragraph

Article in Chinese medical journal, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 16 registered trials, which are not on this map. Cited by 2,061 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2,061citing papers in PubMed, 6 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05976893 phase4unknown statusstarted 2023, after this paper: background citation

Study on the Composite Endpoint Event of PCSK9 Inhibitor in Patients With Very High Risk of ASCVD and Cancer

Ran2023Enrolled620Registered outcomes5Posted comparisons0ConditionsASCVD, Atherosclerotic Cardiovascular Disease, Cancer, Proprotein Convertase Subtilisin/Kexin Type 9 InhibitorArmsEvolocumab, Statin
Open the trial in the graph
NCT05587192 naunknown statusnot on this map

Radical Prostatectomy Without Prostate Biopsy Following 18F-PSMA-1007 PET/CT Based on a Diagnostic Model: a Single-center, Single-arm, Open-label Study

TypeinterventionalSponsorAnhui Provincial HospitalRan2022 to 2024Enrolled57ConditionsProstate CancerArms18F-PSMA-1007 PET/CT based on diagnostic model
NCT05940415 unknown statusnot on this mapstarted 2023, after this paper: background citation

Conducting Active Surveillance Without Prostate Biopsy for Patients With Low-risk Suspected Prostate Cancer Based on USTC Diagnostic Model and PSA Level: a Multicenter Prospective Study

TypeobservationalSponsorAnhui Provincial HospitalRan2023 to 2026Enrolled220ConditionsProstate CancerArmsactive surveillance
NCT06215326 narecruitingnot on this mapstarted 2024, after this paper: background citation

Short-term Effects of Preoperative Exercise in Moderate-to-high Perioperative Risk Lung Cancer Patients(PRE-EXELUCA): a Prospective Randomized Controlled Clinical Trial

TypeinterventionalSponsorGuangdong Provincial People's HospitalRan2024 to 2027Enrolled100ConditionsLung CancerArmsmoderate-intensity continuous training, high-intensity interval training
NCT06219083 recruitingnot on this map

Study of Nutritional Status and Clinical Outcomes in Patients With Common Malignancies

Typeobservational_patient_registrySponsorXiaoqin LuoRan2020 to 2031Enrolled1,538ConditionsCancer, Chemoradiotherapy, Nutrition, Healthy, Oncology
NCT06306612 narecruitingnot on this mapstarted 2024, after this paper: background citation

Systemic Therapy Combined With Cytoreductive Prostatectomy for the Treatment of de Novo Poly-metastatic Hormone Sensitive Prostate Cancer: A Prospective, Open-label Randomized Controlled Trial

TypeinterventionalSponsorRenJi HospitalRan2024 to 2028Enrolled192ConditionsProstate CancerArmsSystemic Chemohormonal Therapy, Systemic Hormonal Therapy, Cytoreductive Prostatectomy, Postoperative Adjuvant Radiotherapy
NCT06518018 unknown statusnot on this mapstarted 2023, after this paper: background citation

Exploring the Efficacy and Safety of High-Dose Rate Brachytherapy Combined With Immunotherapy and Chemotherapy as a Second-Line Treatment in Patients With Advanced Non-Small Cell Lung Cancer: A Single-Center, Retrospective, Propensity Score-Matched Study

TypeobservationalSponsorThe First People's Hospital of NeijiangRan2023 to 2025Enrolled80ConditionsAdvanced Stage NSCLC, Second-line Treatment, Patients Without Targetable Driver MutationsArmsHDR brachytherapy (30Gy single fraction), Immunotherapy
NCT06518655 recruitingnot on this mapstarted 2024, after this paper: background citation

Exploratory Study on the Identification of Benign and Malignant Pulmonary Nodules Using Volatile Organic Compounds in Human Exhaled Breath

TypeobservationalSponsorChromX HealthRan2024 to 2027Enrolled3,000ConditionsPulmonary Nodules, Multiple, Pulmonary Nodules, Solitary, Lung CancerArmsGas chromatography-mass spectrometry(GC-MS) and micro Gas Chromatography-photoionisation detector (μGC-PID) system
NCT06687408 recruitingnot on this mapstarted 2025, after this paper: background citation

Sleeve Lobectomy for Lung Cancer in Minimally Invasive Surgical Techniques: a Multicenter Cohort Study

TypeobservationalSponsorSecond Affiliated Hospital, Zhejiang University, School of MedicineRan2025 to 2027Enrolled450ConditionsLung Cancer, Non-Small CellArmsRATS Group, VATS group
NCT06893133 recruitingnot on this mapstarted 2025, after this paper: background citation

Personalized ctDNA-MRD in Recurrence Monitoring for Gastric Cancer Patients Undergoing Perioperative Treatment Combined With Curative Surgical Resection

TypeobservationalSponsorPeking UniversityRan2025 to 2027Enrolled110ConditionsGastric Cancer
NCT07087561 narecruitingnot on this mapstarted 2024, after this paper: background citation

The Effects and Mechanisms of Short-Term Nutritional Enhancement Combined With Health Education on Clinical Outcomes in Postoperative Patients With Colorectal Cancer: A Multicenter, Open-Label, Randomized Controlled Trial

TypeinterventionalSponsorXiaoqin LuoRan2024 to 2030Enrolled360ConditionsColorectal Cancer (Diagnosis), Malnutrition or Risk of MalnutritionArmsPersonalized Oral Nutritional Supplementation, Personalized Parenteral Nutritional Supplementation, Structured Nutrition-Focused Health Education
NCT07205497 phase2active not recruitingnot on this mapstarted 2025, after this paper: background citation

Iparomlimab and Tuvonralimab (QL1706) Combined With Neoadjuvant Chemotherapy Followed by Type I Hysterectomy for Locally Advanced Cervical Cancer(QNACTH): A Prospective, Single-Arm, Multicenter, Phase 2 Trial

TypeinterventionalSponsorSun Yat-Sen Memorial Hospital of Sun Yat-Sen UniversityRan2025 to 2030Enrolled54ConditionsNeoadjuvant Immunotherapy, Locally Advanced Cervical CancerArmsQL1706+TC
NCT07413354 phase2recruitingnot on this mapstarted 2026, after this paper: background citation

Tislelizumab Combined With Huaier Granule as First-line Treatment for Unresectable Hepatocellular Carcinoma: A Single-arm Prospective Clinical Trial

TypeinterventionalSponsorTongji HospitalRan2026 to 2027Enrolled94ConditionsHepatocellular Carcinoma (HCC)ArmsTislelizumab plus Huaier granule
NCT07420036 early_phase1not yet recruitingnot on this mapstarted 2026, after this paper: background citation

An Open-label, Single-arm, Single-center Study to Evaluate the Diagnostic Efficacy of a Novel PET Probe, 68Ga-SFB6-ZN01, in Patients With Malignant Tumors

TypeinterventionalSponsorZhongnan HospitalRan2026 to 2028Enrolled98ConditionsNeoplasmsArms68Ga-SFB6-ZN01
NCT07643350 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

Comparison of the Efficacy and Safety of Induction Benmelstobart Plus Anlotinib and Chemotherapy Followed by Concurrent Chemoradiotherapy and Benmelstobart Maintenance Versus Concurrent Chemoradiotherapy Followed by Benmelstobart Maintenance in Patients With Unresectable Stage III NSCLC: A Randomized, Controlled, Multicenter Phase II Clinical Study

TypeinterventionalSponsorThe Third Xiangya Hospital of Central South UniversityRan2026 to 2031Enrolled152ConditionsNSCLCArmsBenmelstobart, benmelstobart combined with chemotherapy and anlotinib
NCT07691632 phase2not yet recruitingnot on this mapstarted 2026, after this paper: background citation

A Single-Arm, Single-Center, Phase II Exploratory Clinical Study of Serplulimab Combined With Decitabine Plus CAPOX as Neoadjuvant Therapy for Locally Advanced Colorectal Cancer

TypeinterventionalSponsorTianjin Medical University Cancer Institute and HospitalRan2026 to 2027Enrolled35ConditionsLocally Advanced Colorectal Cancer, Colorectal AdenocarcinomaArmsSerplulimab + Decitabine + CAPOX (Oxaliplatin + Capecitabine)
3 · Its place in the literature

Who cites it

2,061 citing papers in PubMed, 6 syntheses or guidelines pooled it.

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2,001 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Changfa XiaOffice of Cancer Screening, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Xuesi Dong
He Li
Maomao Cao
Dianqin Sun
Siyi He
Fan Yang
Xinxin Yan
Shaoli Zhang
Ni Li
Wanqing Chen

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe cancer burden in the United States of America (USA) has decreased gradually. However, China is experiencing a transition in its cancer profiles, with greater incidence of cancers that were previously more common in the USA. This study compared the latest cancer profiles, trends, and determinants between China and USA.

methodsThis was a comparative study using open-source data. Cancer cases and deaths in 2022 were calculated using cancer estimates from GLOBOCAN 2020 and population estimates from the United Nations. Trends in cancer incidence and mortality rates in the USA used data from the Surveillance, Epidemiology, and End Results program and National Center for Health Statistics. Chinese data were obtained from cancer registry reports. Data from the Global Burden of Disease 2019 and a decomposition method were used to express cancer deaths as the product of four determinant factors.

resultsIn 2022, there will be approximately 4,820,000 and 2,370,000 new cancer cases, and 3,210,000 and 640,000 cancer deaths in China and the USA, respectively. The most common cancers are lung cancer in China and breast cancer in the USA, and lung cancer is the leading cause of cancer death in both. Age-standardized incidence and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently, but rates of liver cancer have increased slightly. Rates of stomach, liver, and esophageal cancer decreased gradually in China, but rates have increased for colorectal cancer in the whole population, prostate cancer in men, and other seven cancer types in women. Increases in adult population size and population aging were major determinants for incremental cancer deaths, and case-fatality rates contributed to reduced cancer deaths in both countries.

conclusionsThe decreasing cancer burden in liver, stomach, and esophagus, and increasing burden in lung, colorectum, breast, and prostate, mean that cancer profiles in China and the USA are converging. Population aging is a growing determinant of incremental cancer burden. Progress in cancer prevention and care in the USA, and measures to actively respond to population aging, may help China to reduce the cancer burden.

Indexed as

Breast NeoplasmsLiver NeoplasmsNeoplasmsAdultChinaFemaleHumansIncidenceMaleRegistriesUnited States

Identifiers

PMID35143424
PMCPMC8920425

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.