ArticleCirculation2022
Fetal Brain Volume Predicts Neurodevelopment in Congenital Heart Disease.
Article in Circulation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 94 papers, 4 of them syntheses that pooled it.
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Who cites it
94 citing papers in PubMed, 4 syntheses or guidelines pooled it, 139 citations in OpenAlex.
- [Neurodevelopmental assessment of children with congenital heart disease: a Meta analysis based on the Bayley Scales of Infant Development and Wechsler Intelligence Scale].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2026Pooled it
- Neurosonographic Evaluation of Cerebral Cortical Development in Fetuses With Congenital Heart Disease: A Systematic Review of the Literature.Prenatal diagnosis · 2025Pooled it
- Clinical practice guidelines for the care of girls and women with Turner syndrome.European journal of endocrinology · 2024Guideline
- Meta-regression of sulcal patterns, clinical and environmental factors on neurodevelopmental outcomes in participants with multiple CHD types.Cerebral cortex (New York, N.Y. : 1991) · 2024Pooled it
- Progesterone for Neurodevelopment in Fetuses With Congenital Heart Defects: A Randomized Clinical Trial.JAMA network open · 2024Trial
- Neurological Development in Very Low Birth Weight Infants with Congenital Heart Disease at 3 Years of Age: A Japanese Multicenter Study.Pediatric cardiology · 2026Article
- Opening editorial for the BMC Anesthesiology collection: recent advances in anesthesia for congenital cardiac diseases.BMC anesthesiology · 2026Article
- Placental hypoplasia and vascular malperfusion are associated with reduced brain volumes in fetal congenital heart disease.Pediatric research · 2026Article
- Linking maternal blood pressure with fetal cerebral haemodynamics and cortical growth in congenital heart disease.EBioMedicine · 2026Article
- Academic Achievements in Adolescents With Congenital Heart Disease: A Total Population-Based Cohort Study.Journal of the American Heart Association · 2026Article
- Association of Fetal Cerebrovascular Resistance and Neurodevelopment in Congenital Heart Disease: A Physiology-Based Analysis.Prenatal diagnosis · 2026Article
- Brain volumes in fetuses with congenital heart disease and placental vascular abnormalities.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Cortical structure alterations in toddlers with different severities of congenital heart disease: a cross-sectional study.European journal of pediatrics · 2026Article
- Environmental Exposures Influence Fetal Brain Growth and Risk of Neonatal Brain Injury in Congenital Heart Disease.Pediatric cardiology · 2026Article
- Prenatal parental mental health and neurodevelopment in children with congenital heart disease.Pediatric research · 2026Review
- Increased risk of neurodevelopmental impairment associated with reduced brain volume at term-equivalent age in preterm infants with germinal matrix hemorrhage.Neuroradiology · 2026Article
- Brain-body interactions in systemic diseases: a survey from an imaging perspective.MedScience · 2026Review
- Deep learning in fetal, infant, and toddler neuroimaging research.Developmental cognitive neuroscience · 2026Review
- Prenatal maternal psychological distress is associated with neurodevelopmental outcomes in toddlers with congenital heart disease.Pediatric research · 2026Article
- Advances in automated fetal brain MRI segmentation and biometry: Insights from the FeTA 2024 challenge.Medical image analysis · 2026Article
34 more citing papers are in PubMed but not listed here.
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Authors and funding
16 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundNeurodevelopmental impairment is common in children with congenital heart disease (CHD), but postnatal variables explain only 30% of the variance in outcomes. To explore whether the antecedents for neurodevelopmental disabilities might begin in utero, we analyzed whether fetal brain volume predicted subsequent neurodevelopmental outcome in children with CHD.
methodsFetuses with isolated CHD and sociodemographically comparable healthy control fetuses underwent fetal brain magnetic resonance imaging and 2-year neurodevelopmental evaluation with the Bayley Scales of Infant and Toddler Development, Third Edition (Bayley-III) and the Adaptive Behavior Assessment System, Third Edition (ABAS-3). Hierarchical regression evaluated potential predictors of Bayley-III and ABAS-3 outcomes in the CHD group, including fetal total brain volume adjusted for gestational age and sex, sociodemographic characteristics, birth measures, and medical history.
resultsThe CHD group (n=52) had lower Bayley-III cognitive, language, and motor scores than the control group (n=26), but fetal brain volumes were similar. Within the CHD group, larger fetal total brain volume correlated with higher Bayley-III cognitive, language, and motor scores and ABAS-3 adaptive functioning scores (
conclusionsSmall fetal brain volume is a strong independent predictor of 2-year neurodevelopmental outcomes and may be an important imaging biomarker of future neurodevelopmental risk in CHD. Future studies are needed to support this hypothesis. Our findings support inclusion of fetal brain volume in risk stratification models and as a possible outcome in fetal neuroprotective intervention studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.