Evidence map›Paper›PMID 35143205›Full record

ArticleThe Journal of organic chemistry2022

Regeneration of Free Reducing Glycans from Reductive Amination-Tagged Glycans by Oxone.

Qing Zhang, Shuaishuai Wang, Zhonghua Li, Yi Lasanajak, Lei Li, Xuezheng Song

Abstract read
In one paragraph

Article in The Journal of organic chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Qing ZhangDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-0203-4437
Shuaishuai WangDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30302, United States.ORCID 0000-0002-8346-9159
Zhonghua LiDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0002-7625-7043
Yi LasanajakEmory Glycomics and Molecular Interactions Core, Emory University School of Medicine, Atlanta, Georgia 30322, United States.
Lei LiDepartment of Chemistry, Georgia State University, Atlanta, Georgia 30302, United States.ORCID 0000-0002-1146-0761
Xuezheng SongDepartment of Biochemistry, Emory University School of Medicine, Atlanta, Georgia 30322, United States.ORCID 0000-0003-1751-2785

Funding

A Comprehensive 5K Plus Glycan MicroarrayR44GM123820 · NIGMS · Z BIOTECH, LLC · PI LI, LEI, ZHANG, JIAN · 2021 to 2023
$1.9M
Natural Glycans for Functional GlycomicsR44GM133252 · NIGMS · NATGLYCAN, LLC · PI SMITH, DAVID FLETCHER · 2020 to 2021
$1.9M
Facile Chemical Methods for Reverse Synthesis and Large Scale Production of Biomedically Relevant Glycan LibrariesU01GM116254 · NIGMS · EMORY UNIVERSITY · PI REINHOLD, VERNON NYE, SONG, XUEZHENG · 2015 to 2017
$1.6M
Next Generation Glycan Microarray using DNA-coded glycans and Next Generation Sequencing (NGS)R01GM137011 · NIGMS · EMORY UNIVERSITY · PI SONG, XUEZHENG · 2020 to 2023
$1.3M
Natural Glycans for Functional GlycomicsR43GM133252 · NIGMS · NATGLYCAN, LLC · PI SMITH, DAVID FLETCHER · 2019 to 2019
$300k
A Natural Glycan Array of the Human Milk GlycomeR43GM131534 · NIGMS · NATGLYCAN, LLC · PI SMITH, DAVID FLETCHER · 2019 to 2020
$289k
NIGMS NIH HHS R01 GM137011NIGMS NIH HHS R43 GM131534NIGMS NIH HHS R43 GM133252NIGMS NIH HHS R44 GM123820NIGMS NIH HHS R44 GM133252NIGMS NIH HHS U01 GM116254
6 · The paper itself

Abstract

Glycans are usually fluorescently tagged by reductive amination for analytic tools. However, free reducing glycan regeneration is sometimes important and necessary for further structural or functional studies. Here, we introduce a new method for efficiently removing fluorescent tags from glycoconjugates by a simple treatment with Oxone. This method is proven to be fast and general after being tested on a series of common saccharides and widely used tags. We successfully achieved

Indexed as

GlycoconjugatesPolysaccharidesAminationRegenerationSulfuric AcidsGlycoconjugatesPolysaccharidespotassium peroxymonosulfuric acidSulfuric Acids

Identifiers

PMID35143205
PMCPMC9228866

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.