SynthesisEuropean journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology2022
Clinical patterns of somatic symptoms in patients suffering from post-acute long COVID: a systematic review.
Synthesis in European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers, 5 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
51 citing papers in PubMed, 5 syntheses or guidelines pooled it, 89 citations in OpenAlex.
- A systematic review to find link between past psychiatric history and development of long covid.BMC psychiatry · 2025Pooled it
- Post-COVID-19 dyspnoea and pulmonary imaging: a systematic review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- SARS-CoV-2 post-acute sequelae in previously hospitalised patients: systematic literature review and meta-analysis.European respiratory review : an official journal of the European Respiratory Society · 2023Pooled it
- Living with "long COVID": A systematic review and meta-synthesis of qualitative evidence.PloS one · 2023Pooled it
- The incidence and risk factors of selected drug prescriptions and outpatient care after SARS-CoV-2 infection in low-risk subjects: a multicenter population-based cohort study.Frontiers in public health · 2023Pooled it
- Developing a job retention vocational rehabilitation intervention for people with long covid: a person-based approach.BMJ open · 2026Article
- Predictors of Long COVID: older adults, women, and an incomplete COVID-19 vaccination schedule.Revista latino-americana de enfermagem · 2026Article
- Patient Experience from a Pilot Study Implementing Software-Based Post-COVID Case Management in GP Practices-A Qualitative Process Evaluation.Healthcare (Basel, Switzerland) · 2025Article
- Lingering symptoms in non-hospitalized patients with COVID-19 - a prospective survey study of symptom expression and effects on mental health in Germany.BMC primary care · 2025Article
- Risk of poor nutritional status and nutrition-related complaints in individuals attending a primary care dietitian after a COVID-19 infection: A prospective cohort study.Nutrition & dietetics : the journal of the Dietitians Association of Australia · 2025Observational
- Wearable data reveals distinct characteristics of individuals with persistent symptoms after a SARS-CoV-2 infection.NPJ digital medicine · 2025Article
- The incidence of outpatient care within 24 months from SARS-CoV-2 infection in the general population: a multicenter population-based cohort study.BMC infectious diseases · 2025Article
- Self-Reported Dyspnea Is Associated with Reduced Health-Related Quality of Life in Quaternary Hospital Workers 1 Year Post Mild COVID-19 Infection.Healthcare (Basel, Switzerland) · 2024Article
- The association between underlying conditions, risk factors, risk markers, and post-COVID conditions ≥6 months after COVID-19: A systematic review.Journal of family medicine and primary care · 2024Article
- Post-Coronavirus Disease 2019 Effects in an Active University Population: A Within-Campus Cross-Sectional Study at a Major Educational Institution.Mayo Clinic proceedings. Innovations, quality & outcomes · 2024Article
- Rehabilitative interventions in patients with persistent post COVID-19 symptoms-a review of recent advances and future perspectives.European archives of psychiatry and clinical neuroscience · 2024Review
- Long-term course and factors influencing work ability and return to work in post-COVID patients 12 months after inpatient rehabilitation.Journal of occupational medicine and toxicology (London, England) · 2024Article
- Article
- Constitution of Long COVID illness, patienthood and recovery: a critical synthesis of qualitative studies.BMJ open · 2024Article
- Potential Impact of Long COVID-19 on Orthodontic Treatment.European journal of dentistry · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLong COVID-19 may affect patients after hospital discharge.
aimsThis study aims to describe the burden of the long-term persistence of clinical symptoms in COVID-19 patients.
methodsWe conducted a systematic review by using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) guideline. The PubMed and Google Scholar databases were searched for studies that included information on the prevalence of somatic clinical symptoms lasting at least 4 weeks after the onset of a PCR- or serology-confirmed diagnosis of COVID-19. The prevalence of persisting clinical symptoms was assessed and risk factors were described when investigated. Psychological symptoms and cognitive disorders were not evaluated in this study.
resultsThirty-seven articles met the inclusion criteria. Eighteen studies involved in-patients only with a duration of follow-up of either less than 12 weeks, 12 weeks to 6 months, or more. In these studies, fatigue (16-64%), dyspnea (15-61%), cough (2-59%), arthralgia (8-55%), and thoracic pain (5-62%) were the most frequent persisting symptoms. In nineteen studies conducted in a majority of out-patients, the persistence of these symptoms was lower and 3% to 74% of patients reported prolonged smell and taste disorders. The main risk factors for persisting symptoms were being female, older, having comorbidities and severity at the acute phase of the disease.
conclusionCOVID-19 patients should have access to dedicated multidisciplinary healthcare allowing a holistic approach. Effective outpatient care for patients with long-COVID-19 requires coordination across multiple sub-specialties, which can be proposed in specialized post-COVID units.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.