SynthesisPediatric surgery international2022
The prevalence and clinical presentation of Hirschsprung's disease in preterm infants: a systematic review and meta-analysis.
Synthesis in Pediatric surgery international, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Subtypes of Enteric Neurons in Hirschsprung Disease: A Comparison of Fully Ganglionic and Transitional Zone.Neurogastroenterology and motility · 2026Article
- Precision minimally invasive strategy for Hirschsprung's disease: from anatomical resection to whole-cycle functional management-a review.Frontiers in pediatrics · 2026Review
- Hirschsprung disease.Nature reviews. Disease primers · 2023Review
- A Case Report of Hirschsprung's Disease in a Neonate: Early Detection and Review of Management.Cureus · 2023Article
- Systematic Review of the Prevalence of Gastrointestinal Congenital Anomalies: A Global and Regional Review Protocol.Sage open pediatricsReview
- The Global Burden of Major Gastrointestinal Anomalies: A Global, Systematic Review of Gastrointestinal Anomaly Birth Prevalence.Sage open pediatricsReview
Corrections and comments
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Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
purposeHirschsprung's disease (HD) is a rare occurrence in premature infants, and the exact prevalence varying across studies. Thus, we conducted this study to determine the prevalence of and clinical presentation of HD in preterm infants.
methodsThe PubMed, EmBase, and Cochrane library databases were searched for eligible studies throughout May 2021. The pooled incidence with 95% confidence interval (CI) was calculated using the random-effects model.
resultsThirty studies involved 4,557 children with HD were included. The pooled proportion of HD patients who were preterm infants was 7% (95% CI 5-8%; P < 0.001); the sensitivity analysis indicated that the pooled prevalence of preterm infants with HD ranged from 5.0% to 5.6%. Moreover, the pooled incidence of abdominal distention in HD patients was 83% (P < 0.001), that of vomiting was 61% (P < 0.001), that of bilious vomiting was 54% (P < 0.001), that of delayed meconium passage was 48% (P < 0.001), that of constipation was 44% (P < 0.001), and that of enterocolitis was 13% (P < 0.001).
conclusionsThis study reported the prevalence of HD patients who were preterm infants, and the most common presentations were abdominal distention, vomiting, bilious vomiting, delayed meconium passage, constipation, and enterocolitis.
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Registered trials
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