Evidence map›Paper›PMID 35142559›Full record

ArticleJournal of applied physiology (Bethesda, Md. : 1985)2022

Aerobic exercise training improves endothelial function and attenuates blood pressure reactivity during maximal exercise in chronic kidney disease.

Justin D Sprick, Kevin Mammino, Jinhee Jeong, Dana R DaCosta, Yingtian Hu, Doree G Morison, Joe R Nocera, Jeanie Park

Open access · greenAbstract read
In one paragraph

Article in Journal of applied physiology (Bethesda, Md. : 1985), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 2 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 2 syntheses or guidelines pooled it, 26 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Trial
  4. Trial
  5. Trial
  6. Trial
  7. Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026
    Review
  8. Article
  9. Review
  10. Endothelial dysfunction in chronic kidney disease: a clinical perspective.American journal of physiology. Heart and circulatory physiology · 2025
    Review
  11. Article
  12. Nephrologists' Insights on Exercise in Renal Health.Kidney & blood pressure research · 2025
    Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Neurocirculatory regulation and adaptations to exercise in chronic kidney disease.American journal of physiology. Heart and circulatory physiology · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Justin D SprickDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0001-9782-1865
Kevin MamminoDepartment of Veterans Affairs Health Care System, Decatur, Georgia.
Jinhee JeongDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-8748-8429
Dana R DaCostaDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Yingtian HuDepartment of Biostatistics and Bioinformatics, Emory University Rollins School of Public Health, Atlanta, Georgia.
Doree G MorisonDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.
Joe R NoceraDepartment of Veterans Affairs Health Care System, Decatur, Georgia.
Jeanie ParkDivision of Renal Medicine, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-5799-9172
Emory University · USAtlanta VA Health Care System · US

Funding

Neurovascular Regulation During Exercise In Humans With Chronic Kidney DiseaseR01HL135183 · NHLBI · EMORY UNIVERSITY · PI Jeanie Park · 2017 to 2026
$5.4M
Sympatho-inhibition with Mindfulness in Chronic Kidney DiseaseR61AT010457 · NCCIH · EMORY UNIVERSITY · PI PARK, JEANIE · 2019 to 2020
$946k
Intramuscular Mechanisms Regulating Neurocirculatory Control in Chronic Kidney DiseaseF32HL147547 · NHLBI · EMORY UNIVERSITY · PI SPRICK, JUSTIN DANIEL · 2019 to 2021
$161k
Mechanisms of Sympathetic Overactivity in Post-traumatic Stress DisorderI01CX001065 · VA · VETERANS HEALTH ADMINISTRATION · PI PARK, JEANIE · 2015 to 2024
–
CSRD VA I01 CX001065NCCIH NIH HHS R61 AT010457NCCIH NIH HHS R61AT010457NHLBI NIH HHS F32 HL147547NHLBI NIH HHS F32HL147547NHLBI NIH HHS R01 HL135183NHLBI NIH HHS R01HL135183
6 · The paper itself

Abstract

Patients with chronic kidney disease (CKD) have exaggerated increases in blood pressure during exercise that are associated with endothelial dysfunction. We hypothesized that aerobic exercise training would improve endothelial function and attenuate blood pressure reactivity during exercise in CKD. Sedentary individuals with CKD stages III-IV underwent 12 wk of aerobic cycling exercise (

Indexed as

ExerciseRenal Insufficiency, ChronicBlood PressureExercise TestExercise TherapyFemaleHumansMaleexercise testinghypertensionneural control of circulationreactive hyperemia indexV̇o2peak

Identifiers

PMID35142559
PMCPMC8917938
OpenAlexW4211079515

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.