ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2022
Human Gut Antibiotic Resistome and Progression of Diabetes.
Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 74 citations in OpenAlex.
- Profiling the gut resistome to unlock antimicrobial resistance biology and inform clinical risk.Nature communications · 2026Review
- Gut microbial community structure, metabolic signature, and resistome in dyslipidemia: implications for cardiovascular disease management.Microbiology spectrum · 2026Article
- Microbiota-metabolites interaction associated with glycemic improvement following a dietary herbal intervention in type 2 diabetes.Frontiers in nutrition · 2026Article
- Dynamics of the gut microbiome and resistome in response to prophylactic antibiotic treatment in post-surgical giant pandas.Scientific reports · 2025Article
- The Gut Resistome Atlas in Preterm Infants Enables Prediction of Necrotizing Enterocolitis Onset.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Quantifying antibiotic resistome risks across environmental niches: the L-ARRAP for long-read metagenomic profiling.Briefings in bioinformatics · 2025Article
- Integrative systems biology approaches for analyzing microbiome dysbiosis and species interactions.Briefings in bioinformatics · 2025Review
- Selective expansion of gut antibiotic resistome and underlying pathways involved in type 1 diabetes.iMetaOmics · 2025Article
- Long-Term or Recurrent Antibiotic Use in Early Life and the Risk of Type 2 Diabetes: A Population-Based Prospective Cohort and a Case-Control Study.Journal of diabetes · 2025Article
- The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial.BMC microbiology · 2025Article
- Altered gut microbiota and metabolite profiles in community-acquired pneumonia: a metagenomic and metabolomic study.Microbiology spectrum · 2025Article
- Metagenomics Disentangles Differential Resistome Traits and Risks in Full-Scale Anaerobic Digestion Plants under Ambient, Mesophilic, and Thermophilic Conditions.ACS environmental Au · 2025Article
- Machine Learning Models Integrating Dietary Indicators Improve the Prediction of Progression from Prediabetes to Type 2 Diabetes Mellitus.Nutrients · 2025Article
- Food substances alter gut resistome: Mechanisms, health impacts, and food components.Comprehensive reviews in food science and food safety · 2025Review
- Potential roles of cigarette smoking on gut microbiota profile among Chinese men.BMC medicine · 2025Article
- Effect of folpet on hypoglycaemia, intestinal microbiota, and drug resistance genes in mice.BMC microbiology · 2025Article
- metaExpertPro: A Computational Workflow for Metaproteomics Spectral Library Construction and Data-Independent Acquisition Mass Spectrometry Data Analysis.Molecular & cellular proteomics : MCP · 2024Article
- A permutable MLP-like architecture for disease prediction from gut metagenomic data.BMC bioinformatics · 2024Article
- Gut resistome linked to sexual preference and HIV infection.BMC microbiology · 2024Article
- Cohort Profile: Guangzhou Nutrition and Health Study (GNHS): A Population-based Multi-omics Study.Journal of epidemiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 2 institutions in 1 country.
Funding
Abstract
The antibiotic resistance crisis underlies globally increasing failures in treating deadly bacterial infections, largely due to the selection of antibiotic resistance genes (ARG) collection, known as the resistome, in human gut microbiota. So far, little is known about the relationship between gut antibiotic resistome and host metabolic disorders such as type 2 diabetes (T2D). Here, metagenomic landscape of gut antibiotic resistome is profiled in a large multiomics human cohort (n = 1210). There is a significant overall shift in gut antibiotic resistome structure among healthy, prediabetes, and T2D groups. It is found that larger ARG diversity is associated with a higher risk of T2D. The novel diabetes ARG score is positively associated with glycemic traits. Longitudinal validation analysis confirms that the ARG score is associated with T2D progression, characterized by the change of insulin resistance. Collectively, the data describe the profiles of gut antibiotic resistome and support its close relationship with T2D progression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.