Evidence map›Paper›PMID 35142428›Full record

ArticleMolecular nutrition & food research2022

Genistein Stimulation of White Adipose Tissue Thermogenesis Is Partially Dependent on GPR30 in Mice.

Saraí Vásquez-Reyes, Ariana Vargas-Castillo, Lilia G Noriega, Laura A Velázquez-Villegas, Berenice Pérez, Mónica Sánchez-Tapia, Guillermo Ordaz, Renato Suárez-Monroy, Alfredo Ulloa-Aguirre, Halina Offner and 2 more

Open access · greenAbstract read
In one paragraph

Article in Molecular nutrition & food research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 8 citations in OpenAlex.

  1. Phytocompounds That Target White Adipose Tissue for Weight Loss: A Review Spanning From Ucp1 Induction in Rodents to Human Clinical Trials.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2026
    Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Deletion ofFrontiers in endocrinology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 2 countries.

Saraí Vásquez-ReyesDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Ariana Vargas-CastilloDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Lilia G NoriegaDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Laura A Velázquez-VillegasDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Berenice PérezDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Mónica Sánchez-TapiaDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Guillermo OrdazDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Renato Suárez-MonroyDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.
Alfredo Ulloa-AguirreRed de Apoyo a la Investigación, Universidad Nacional Autónoma de México-Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, CDMX, México.
Halina OffnerNeuroimmunology Research, R&D-31, VA Portland Health Care System, 3710 SW U.S. Veterans Hospital Rd., Portland, OR, 97239, USA.
Nimbe TorresDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.ORCID 0000-0002-1741-0984
Armando R TovarDepartamento de Fisiología de la Nutrición, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, México, CDMX, México.ORCID 0000-0002-1292-1312
Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán · MXOregon Health & Science University · US

Funding

Compensatory mechanisms of estrogen mediated protection from EAE in IL-10 KO miceR21AI148409 · NIAID · OREGON HEALTH & SCIENCE UNIVERSITY · PI OFFNER, HALINA · 2020 to 2021
$347k
NIAID NIH HHS R21 AI148409
6 · The paper itself

Abstract

scopeGenistein increases whole body energy expenditure by stimulating white adipose tissue (WAT) browning and thermogenesis. G-Coupled receptor GPR30 can mediate some actions of genistein, however, it is not known whether it is involved in the activation of WAT-thermogenesis. Thus, the aim of the study is to determine whether genistein activates thermogenesis coupled to an increase in WAT browning and mitochondrial activity, in GPR30 METHODS AND

resultsGPR30

conclusionThe results show that GPR30 partially mediates genistein stimulation of WAT thermogenesis and the improvement of glucose tolerance.

Indexed as

Adipose Tissue, BrownGenisteinAdipose Tissue, WhiteAnimalsBody WeightEnergy MetabolismGlucoseMiceMice, Inbred C57BLThermogenesisGenisteinGlucoseenergy expendituregenisteinglucose toleranceGPR30thermogenesis

Identifiers

PMID35142428
PMCPMC10205097
OpenAlexW4211055380

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.