Evidence map›Paper›PMID 35142393›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2022

Exercise improves angiogenic function of circulating exosomes in type 2 diabetes: Role of exosomal SOD3.

Kareem Abdelsaid, Varadarajan Sudhahar, Ryan A Harris, Archita Das, Seock-Won Youn, Yutao Liu, Maggie McMenamin, Yali Hou, David Fulton, Mark W Hamrick and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
4.0field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 52 citations in OpenAlex.

  1. Exercise Training Stimulates the Release of Glutathione Peroxidase 1 (GPX1)-Enriched Extracellular Vesicles That Promote Angiogenesis.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
    Article
  2. Review
  3. Article
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  17. Article
  18. Exosomes in Diabetic Wound Healing: Mechanisms, Applications, and Perspectives.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025
    Review
  19. EndothelialCurrent diabetes reviews · 2025
    Review
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kareem AbdelsaidVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0002-5759-4714
Varadarajan SudhaharVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Ryan A HarrisGeorgia Prevention Institute, Augusta, Georgia, USA.
Archita DasVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Seock-Won YounVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Yutao LiuDepartment of Cell Biology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Maggie McMenaminVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Yali HouVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
David FultonVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Mark W HamrickDepartment of Cell Biology, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Yaoliang TangVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.
Tohru FukaiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0001-9864-571X
Masuko Ushio-FukaiVascular Biology Center, Medical College of Georgia at Augusta University, Augusta, Georgia, USA.ORCID https://orcid.org/0000-0001-7048-2381
Augusta University · USPrevention Institute · US

Funding

Vascular Extracellular Superoxide Dismutase ModulationR01HL070187 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKAI, TOHRU · 2002 to 2017
$4.2M
Redox Regulation of Cu Importer CTR1 in AngiogenesisR01HL147550 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2020 to 2023
$3.3M
Copper transport protein and inflammatory angiogenesisR01HL116976 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2013 to 2016
$2.9M
Cu Transporting ATPase and Diabetic Vascular ComplicationsR01HL133613 · NHLBI · AUGUSTA UNIVERSITY · PI FUKAI, TOHRU, USHIO-FUKAI, MASUKO · 2017 to 2020
$2.7M
Notch1/miR-322 Axis in Stem Cell Mediated Vascular RepairR01HL134354 · NHLBI · AUGUSTA UNIVERSITY · PI ASHRAF, MUHAMMAD, TANG, YAO LIANG · 2016 to 2020
$2.5M
Mitochondria Dynamics Protein Drp1 in ROS Signaling, Endothelial Metabolism and AngiogenesisR01HL160014 · NHLBI · AUGUSTA UNIVERSITY · PI USHIO-FUKAI, MASUKO · 2021 to 2024
$2.0M
Protein Disulfide Isomerase as Novel Redox Sensor in VEGF SignalingR01HL135584 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI USHIO-FUKAI, MASUKO · 2017 to 2020
$1.5M
SUMOylation of Cu transport protein Atox1 in AtherosclerosisI01BX001232 · VA · JESSE BROWN VA MEDICAL CENTER · PI TOHRU FUKAI · 2012 to 2026
–
BLRD VA I01 BX001232NHLBI NIH HHS R01 HL070187NHLBI NIH HHS R01 HL116976NHLBI NIH HHS R01 HL133613NHLBI NIH HHS R01 HL134354NHLBI NIH HHS R01 HL135584NHLBI NIH HHS R01 HL147550NHLBI NIH HHS R01 HL160014
6 · The paper itself

Abstract

Exosomes, key mediators of cell-cell communication, derived from type 2 diabetes mellitus (T2DM) exhibit detrimental effects. Exercise improves endothelial function in part via the secretion of exosomes into circulation. Extracellular superoxide dismutase (SOD3) is a major secretory copper (Cu) antioxidant enzyme that catalyzes the dismutation of O

Indexed as

Neovascularization, PhysiologicRunningAnimalsCells, CulturedCopper-Transporting ATPasesDiabetes Mellitus, Type 2Endothelium, VascularExerciseExosomesFemaleHumansMaleMiceMice, Inbred C57BLMiddle AgedPhysical Conditioning, AnimalAtp7a protein, mouseCopper-Transporting ATPasesSod3 protein, mouseSuperoxide DismutaseexerciseexosomeSOD3type 2 diabetes

Identifiers

PMID35142393
PMCPMC8880294
OpenAlexW4211066528

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.