Evidence map›Paper›PMID 35142365›Full record

ArticleHistology and histopathology2022

The clinicopathological and prognostic significances of LATS1 expression in breast cancer.

Hua-Chuan Zheng, Li-Wei Xiang, Zheng-Guo Cui, Hang Xue, Ying E, Ming-Zhen Zhao

Abstract read
PubMed Publisher
In one paragraph

Article in Histology and histopathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.1field-weighted citation impact, top 62% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Hua-Chuan Zheng *Department of Oncology and Experimental Center, The Affiliated Hospital of Chengde Medical University, Chengde, China. zheng_huachuan@hotmail.com.
Li-Wei Xiang *Department of Oncology and Experimental Center, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Zheng-Guo CuiDepartment of Environmental Health, University of Fukui School of Medical Science, Fukui, Japan.
Hang XueDepartment of Oncology and Experimental Center, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Ying EDepartment of Oncology, Liaoning Cancer Hospital, Shenyang, China.
Ming-Zhen ZhaoDepartment of Respiratory Medicine, The Affiliated Hospital of Chengde Medical University, Chengde, China.
Chengde Medical University · CNLiaoning Cancer Hospital & Institute · CNUniversity of Fukui · JP

Funding

Award for Liaoning Distinguished Professor, Natural Science Foundation of Hebei Province 202130821010436Award for Liaoning Distinguished Professor, Natural Science Foundation of Hebei Province 21377772DNatural Scientific Foundation of China 81672700
6 · The paper itself

Abstract

aimLarge tumor suppressor gene 1 (LATS1) belongs to the PKA/PKG/PKC serine/threonine kinase subfamily of the Hippo signaling pathway and inactivates nuclear co-activators YAP1 and WWTR1 by phosphorylation. This study aimed to discern the clinicopathological and prognostic significances of LATS1 expression in breast cancer.

methodsWe examined LATS1 expression in breast carcinogenesis and compared it with clinicopathological parameters and survival information of breast cancer patients using immunohistochemistry, western blotting, RT-PCR, and bioinformatics analysis.

resultsLATS1 expression was downregulated in breast cancer at both mRNA and protein levels (P<0.05). LATS1 mRNA expression was negatively correlated with low ER and PR expression, aggressive subtypes (TNBC and HER2+ vs. luminal), and poor survival (P<0.05). Its protein expression was negatively linked to patient age, T stage, N stage, M stage histological grade, PR status, and unfavorable prognosis (P<0.05). There was a positive correlationship between nuclar and cytoplasmic LATS1 expression in breast cancer (P<0.05).

conclusionsThe downregulation of LATS1 expression plays a vital role in the carcinogenesis and progression of breast cancer. Thus, LATS1 loss was employed to indicate the aggressive behaviors and poor prognosis of breast cancer.

Indexed as

Breast NeoplasmsCarcinogenesisFemaleGene Expression Regulation, NeoplasticHumansPrognosisProtein Serine-Threonine KinasesRNA, MessengerSerineLATS1 protein, humanProtein Serine-Threonine KinasesRNA, MessengerSerine

Identifiers

PMID35142365
OpenAlexW4211246676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.