Evidence map›Paper›PMID 35142288›Full record

ArticleeLife2022

Cdc6 is sequentially regulated by PP2A-Cdc55, Cdc14, and Sic1 for origin licensing in

Jasmin Philip, Mihkel Örd, Andriele Silva, Shaneen Singh, John Fx Diffley, Dirk Remus, Mart Loog, Amy E Ikui

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.9field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Jasmin PhilipThe PhD Program in Biochemistry, The Graduate Center, CUNY, Brooklyn, United States.ORCID 0000-0001-9030-9228
Mihkel ÖrdUniversity of Tartu, Tartu, Estonia.
Andriele SilvaThe PhD Program in Biochemistry, The Graduate Center, CUNY, Brooklyn, United States.
Shaneen SinghThe PhD Program in Biochemistry, The Graduate Center, CUNY, Brooklyn, United States.
John Fx DiffleyThe Francis Crick Institute, London, United Kingdom.ORCID 0000-0001-5184-7680
Dirk RemusMemorial Sloan-Kettering Cancer Center, New York, United States.ORCID 0000-0002-5155-181X
Mart LoogUniversity of Tartu, Tartu, Estonia.
Amy E IkuiThe PhD Program in Biochemistry, The Graduate Center, CUNY, Brooklyn, United States.ORCID 0000-0002-2712-5351
The Graduate Center, CUNY · USUniversity of Tartu · EEMemorial Sloan Kettering Cancer Center · USThe Francis Crick Institute · GB

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
Mechanism of DNA replication initiation in Saccharomyces cerevisiaeR01GM107239 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI REMUS, DIRK · 2014 to 2023
$3.9M
Cell cycle regulation in response to plasma membrane stress in S. cerevisaeSC1GM121242 · NIGMS · BROOKLYN COLLEGE · PI IKUI, AMY E · 2017 to 2024
$3.0M
Molecular mechanisms of replication-coupled chromatin assemblyR01GM127428 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI REMUS, DIRK · 2019 to 2022
$2.0M
Cancer Research UKMedical Research CouncilNCI NIH HHS P30 CA008748NIGMS NIH HHS R01 GM107239NIGMS NIH HHS R01 GM127428NIGMS NIH HHS SC1 GM121242Wellcome Trust FC001066
6 · The paper itself

Abstract

Cdc6, a subunit of the pre-replicative complex (pre-RC), contains multiple regulatory cyclin-dependent kinase (Cdk1) consensus sites, SP or TP motifs. In

Indexed as

Cell Cycle ProteinsCyclin-Dependent Kinase Inhibitor ProteinsDNA ReplicationMitosisPhosphorylationProtein Phosphatase 2Protein Tyrosine PhosphatasesSaccharomyces cerevisiaeSaccharomyces cerevisiae ProteinsCDC14 protein, S cerevisiaeCDC55 protein, S cerevisiaeCDC6 protein, S cerevisiaeCell Cycle ProteinsCyclin-Dependent Kinase Inhibitor ProteinsProtein Phosphatase 2Protein Tyrosine PhosphatasesSaccharomyces cerevisiae ProteinsSIC1 protein, S cerevisiaeCdc14Cdc55Cdc6cell biologyDNA replicationphosphatasePP2AS. cerevisiae

Identifiers

PMID35142288
PMCPMC8830886
OpenAlexW4220835309

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.