Evidence map›Paper›PMID 35142095›Full record

ArticleESC heart failure2022

Real-world eligibility for vericiguat in decompensated heart failure with reduced ejection fraction.

Jaewon Oh, Chan Joo Lee, Jin Joo Park, Sang Eun Lee, Min-Seok Kim, Hyun-Jai Cho, Jin-Oh Choi, Hae-Young Lee, Kyung-Kuk Hwang, Kye Hun Kim and 9 more

Open access · goldAbstract readMulticenter Study
In one paragraph

Article in ESC heart failure, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 27 citations in OpenAlex.

  1. Vericiguat: A New Horizon for Heart Failure Treatment.Reviews in cardiovascular medicine · 2026
    Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Observational
  7. Article
  8. Article
  9. Article
  10. Vericiguat: The Fifth Harmony of Heart Failure with Reduced Ejection Fraction.Journal of cardiovascular development and disease · 2023
    Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 12 institutions in 3 countries.

Jaewon OhDivision of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Chan Joo LeeDivision of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Jin Joo ParkDivision of Cardiology, Seoul National University Bundang Hospital, Seongnam, Korea.
Sang Eun LeeDivision of Cardiology, Asan Medical Center, Seoul, Korea.
Min-Seok KimDivision of Cardiology, Asan Medical Center, Seoul, Korea.
Hyun-Jai ChoDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Jin-Oh ChoiDepartment of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Korea.
Hae-Young LeeDepartment of Internal Medicine, Seoul National University Hospital, Seoul, Korea.
Kyung-Kuk HwangDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Kye Hun KimDepartment of Internal Medicine, Chonnam National University, Gwangju, Korea.
Byung-Su YooDepartment of Internal Medicine, Yonsei University Wonju College of Medicine, Wonju, Korea.
Dong-Ju ChoiDivision of Cardiology, Seoul National University Bundang Hospital, Seongnam, Korea.
Sang Hong BaekDepartment of Internal Medicine, Catholic University of Korea, Seoul, Korea.
Eun-Seok JeonDepartment of Internal Medicine, Sungkyunkwan University College of Medicine, Seoul, Korea.
Jae-Joong KimDivision of Cardiology, Asan Medical Center, Seoul, Korea.
Myeong-Chan ChoDepartment of Internal Medicine, Chungbuk National University College of Medicine, Cheongju, Korea.
Shung Chull ChaeDepartment of Internal Medicine, Kyungpook National University College of Medicine, Daegu, Korea.
Byung-Hee OhDepartment of Internal Medicine, Mediplex Sejong Hospital, Incheon, Korea.
Seok-Min KangDivision of Cardiology, Department of Internal Medicine, Severance Cardiovascular Hospital, Cardiovascular Research Institute, Yonsei University College of Medicine, 50-1 Yonsei-ro, Seodaemun-gu, Seoul, 03722, Korea.
Asan Medical Center · KRSeoul National University Bundang Hospital · KRSeoul National University Hospital · KRSeverance Hospital · KRSungkyunkwan University · KRYonsei University · KRCatholic University of Korea · KRChonnam National University Hospital · KRKyungpook National University · KRNational University College · PRNew Generation University College · ETSejong General Hospital · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aims In 2021, vericiguat was approved by the US Food and Drug Administration (FDA) and the European Commission (EC) for reducing cardiovascular mortality and heart failure (HF) hospitalizations in patients with HF with reduced ejection fraction (HFrEF) based on the Vericiguat Global Study in Subjects with Heart Failure with Reduced Ejection Fraction (VICTORIA) trial. However, there has been no report for characterizing the generalizability of vericiguat to real-world clinical practice. Methods and results The Korean Acute Heart Failure (KorAHF) registry is a multicentre prospective cohort study. A total of 5625 patients who were admitted for HF decompensation were consecutively enrolled. We excluded the patients without left ventricular ejection fraction (LVEF) quantification, patients with LVEF > 45%, patients with in-hospital death or urgent heart transplantation, and patients without natriuretic peptide measurement. Among a total of 3014 enrolled patients, there were 21.9% patients with lower systolic blood pressure (SBP) (<100 mmHg) and 20.1% patients without elevated natriuretic peptide. Regarding chronic kidney disease (CKD) status, 5.1% patients had CKD Stage V [estimated glomerular filtration rate (eGFR) <15 mL/min/1.73 m

Indexed as

Heart FailureHeterocyclic Compounds, 2-RingHospital MortalityHumansProspective StudiesPyrimidinesStroke VolumeVentricular Function, LeftHeterocyclic Compounds, 2-RingPyrimidinesvericiguatClinical pharmacologyEligibilityHeart failureRegistriesVericiguat

Identifiers

PMID35142095
PMCPMC8934970
OpenAlexW4211040630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.