Evidence map›Paper›PMID 35142084›Full record

ArticleJournal of cachexia, sarcopenia and muscle2022

m

Yuantong Liu, Tianjian Zhou, Qinghe Wang, Runhan Fu, Zengfu Zhang, Nandi Chen, Zhizhong Li, Guoyong Gao, Songlin Peng, Dazhi Yang

Open access · goldAbstract read
In one paragraph

Article in Journal of cachexia, sarcopenia and muscle, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. The role of mNaunyn-Schmiedeberg's archives of pharmacology · 2026
    Review
  4. Article
  5. Article
  6. O-GlcNAcase Inhibitor Improves Denervation-Induced Muscle Atrophy in Mice.Journal of cachexia, sarcopenia and muscle · 2025
    Article
  7. Article
  8. Epigenetics of Skeletal Muscle Atrophy.International journal of molecular sciences · 2024
    Review
  9. Epigenetic control of skeletal muscle atrophy.Cellular & molecular biology letters · 2024
    Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Potential Therapeutic Strategies for Skeletal Muscle Atrophy.Antioxidants (Basel, Switzerland) · 2022
    Review
  16. Article
  17. Review
  18. NCell death discovery · 2022
    Article
  19. mJournal of cachexia, sarcopenia and muscle · 2022
    Article
  20. Regulatory role of RNA NFrontiers in cell and developmental biology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Yuantong LiuDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.ORCID 0000-0003-3672-2489
Tianjian ZhouDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Qinghe WangDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Runhan FuDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, China.
Zengfu ZhangDepartment of Orthopedics, Qilu Hospital of Shandong University, Jinan, China.
Nandi ChenDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Zhizhong LiThe First Affiliated Hospital, Jinan University, Guangzhou, China.
Guoyong GaoDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Songlin PengDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Dazhi YangDepartment of Spine Surgery, Shenzhen People's Hospital, The Second Clinical Medical College, Jinan University, Shenzhen, China.
Jinan University · CNQilu Hospital of Shandong University · CNFirst Affiliated Hospital of Jinan University · CN

Funding

Guangdong Basic and Applied Basic Research Foundation 2019A1515110402National Natural Science Foundation of China 32100915Shenzhen Municipal Science and Technology Innovation Committee Project JCYJ20180305164544288Shenzhen Municipal Science and Technology Innovation Committee Project JCYJ20190807145011340Shenzhen Municipal Science and Technology Innovation Committee Project JSGG20180504170427135Shenzhen Municipal Science and Technology Innovation Committee Project SGLH20180625141602256
6 · The paper itself

Abstract

backgroundSkeletal muscle atrophy is a common clinical manifestation of various neurotrauma and neurological diseases. In addition to the treatment of primary neuropathies, it is a clinical condition that should be investigated. FoxO3 activation is an indispensable mechanism in denervation-induced muscle atrophy; however, upstream factors that control FoxO3 expression and activity have not been fully elucidated. N

methodsWe performed gain-of-function and loss-of-function experiments and used denervation-induced muscle atrophy mouse model to evaluate the effects of m

resultsIn skeletal muscles, denervation was associated with a 20.7-31.9% decrease in m

conclusionsOur findings elucidate on the roles and mechanisms of ALKBH5-mediated m

Indexed as

AlkB Homolog 5, RNA DemethylaseForkhead Box Protein O3Histone DeacetylasesMuscular AtrophyAnimalsDenervationMiceMuscle, SkeletalSignal TransductionALKBH5 protein, mouseAlkB Homolog 5, RNA DemethylaseForkhead Box Protein O3FoxO3 protein, mouseHdac5 protein, mouseHistone DeacetylasesALKBH5DenervationFoxO3HDAC4m6A modificationMuscle atrophy

Identifiers

PMID35142084
PMCPMC8978003
OpenAlexW4211260884

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.