Evidence map›Paper›PMID 35142069›Full record

ArticleAutism research : official journal of the International Society for Autism Research2022

Altered medial prefrontal cortex and dorsal raphé activity predict genotype and correlate with abnormal learning behavior in a mouse model of autism-associated 2p16.3 deletion.

Rebecca B Hughes, Jayde Whittingham-Dowd, Steven J Clapcote, Susan J Broughton, Neil Dawson

Open access · hybridAbstract read
In one paragraph

Article in Autism research : official journal of the International Society for Autism Research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.5field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 21 citations in OpenAlex.

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  9. Protective effect of PDE4B subtype-specific inhibition in an App knock-in mouse model for Alzheimer's disease.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  10. Copy Number Variations in Neuropsychiatric Disorders.International journal of molecular sciences · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Rebecca B HughesDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
Jayde Whittingham-DowdDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
Steven J ClapcoteSchool of Biomedical Sciences, University of Leeds, Leeds, UK.
Susan J BroughtonDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.
Neil DawsonDivision of Biomedical and Life Sciences, Faculty of Health and Medicine, Lancaster University, Lancaster, UK.ORCID 0000-0003-0123-897X
Lancaster University · GBUniversity of Leeds · GB

Funding

Medical Research Council G0900625
6 · The paper itself

Abstract

2p16.3 deletion, involving NEUREXIN1 (NRXN1) heterozygous deletion, substantially increases the risk of developing autism and other neurodevelopmental disorders. We have a poor understanding of how NRXN1 heterozygosity impacts on brain function and cognition to increase the risk of developing the disorder. Here we characterize the impact of Nrxn1α heterozygosity on cerebral metabolism, in mice, using

Indexed as

Autism Spectrum DisorderAutistic DisorderAnimalsDisease Models, AnimalDorsal Raphe NucleusGenotypeHumansMaleMicePrefrontal CortexReversal Learningcognitive neurosciencecopy number variation/copy number variantsfrontal lobegenotype-phenotype correlationimaging geneticsmouse modelsserotonin

Identifiers

PMID35142069
PMCPMC9303357
OpenAlexW4211260707

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.