Evidence map›Paper›PMID 35142053›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022

Deep residual inception encoder-decoder network for amyloid PET harmonization.

Jay Shah, Fei Gao, Baoxin Li, Valentina Ghisays, Ji Luo, Yinghua Chen, Wendy Lee, Yuxiang Zhou, Tammie L S Benzinger, Eric M Reiman and 3 more

Abstract read
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Longitudinal head-to-head comparison ofEuropean journal of nuclear medicine and molecular imaging · 2023
    Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Deep residual inception encoder-decoder network for amyloid PET harmonization.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022
    Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Jay ShahASU-Mayo Center for Innovative Imaging, Arizona State University, 699 S. Mill Ave., Tempe, Arizona, 85287, USA.ORCID 0000-0002-3617-2395
Fei GaoASU-Mayo Center for Innovative Imaging, Arizona State University, 699 S. Mill Ave., Tempe, Arizona, 85287, USA.
Baoxin LiASU-Mayo Center for Innovative Imaging, Arizona State University, 699 S. Mill Ave., Tempe, Arizona, 85287, USA.
Valentina GhisaysBanner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona, 85006, USA.
Ji LuoBanner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona, 85006, USA.
Yinghua ChenBanner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona, 85006, USA.
Wendy LeeBanner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona, 85006, USA.
Yuxiang ZhouDepartment of Radiology, Mayo Clinic at Arizona, 5777 E Mayo Blvd, Phoenix, Arizona, 85054, USA.
Tammie L S BenzingerMallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis, 510 South Kingshighway Boulevard, St. Louis, Missouri, 63110, USA.
Eric M ReimanBanner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona, 85006, USA.
Kewei ChenBanner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, Arizona, 85006, USA.
Yi SuASU-Mayo Center for Innovative Imaging, Arizona State University, 699 S. Mill Ave., Tempe, Arizona, 85287, USA.
Teresa WuASU-Mayo Center for Innovative Imaging, Arizona State University, 699 S. Mill Ave., Tempe, Arizona, 85287, USA.

Funding

WU INSTITUTE OF CLINICAL AND TRANSLATIONAL SCIENCESUL1TR002345 · NCATS · WASHINGTON UNIVERSITY · PI William G. Powderly · 2017 to 2026
$97.8M
Smartphone-Based "Burst" Cognitive AssessmentsP01AG003991 · NIA · WASHINGTON UNIVERSITY · PI JOHN MORRIS · 1985 to 2026
$69.5M
WASHINGTON UNIVERSITY ALZHEIMERS DISEASE RESEARCH CENTERP50AG005681 · NIA · WASHINGTON UNIVERSITY · PI MUSIEK, ERIK STEVEN · 1985 to 2019
$52.1M
The natural history of AB accumulation in preclinical ADP01AG026276 · NIA · WASHINGTON UNIVERSITY · PI MORRIS, JOHN · 2005 to 2025
$49.5M
Washington University Institute of Clinical and Translational SciencesUL1TR000448 · NCATS · WASHINGTON UNIVERSITY · PI EVANOFF, BRADLEY A · 2012 to 2016
$41.4M
Research Education ComponentP30AG019610 · NIA · SUN HEALTH RESEARCH INSTITUTE · PI REIMAN, ERIC MICHAEL · 2001 to 2020
$32.5M
Research Education ComponentP30AG066444 · NIA · WASHINGTON UNIVERSITY · PI DAVID M. HOLTZMAN · 2020 to 2026
$28.7M
APOE in the Predisposition to, Protection from and Prevention of Alzheimer's DiseaseR01AG069453 · NIA · BANNER HEALTH · PI ASHTON, NICHOLAS, LANGBAUM, JESSICA BROOKE · 2020 to 2025
$27.4M
Research Education ComponentP30AG072980 · NIA · BANNER HEALTH · PI Nicholas Ashton · 2021 to 2026
$24.9M
PET, APOE & the Preclinical Course of Alzheimer's DiseaseR01AG031581 · NIA · BANNER ALZHEIMER'S INSTITUTE · PI CASELLI, RICHARD J., REIMAN, ERIC MICHAEL · 2008 to 2018
$16.6M
THE XNAT IMAGING INFORMATICS PLATFORMR01EB009352 · NIBIB · WASHINGTON UNIVERSITY · PI Daniel Scott Marcus · 2009 to 2026
$9.3M
Quantification of Neuroinflammation inAlzheimer's Disease Using Diffusion BasisSpectrum ImagingR01AG054567 · NIA · WASHINGTON UNIVERSITY · PI BENZINGER, TAMMIE LEE SMITH, WANG, YONG · 2017 to 2021
$3.6M
NCATS NIH HHS UL1 TR000448NCATS NIH HHS UL1 TR002345NIA NIH HHS P01 AG003991NIA NIH HHS P01 AG026276NIA NIH HHS P30 AG019610NIA NIH HHS P30 AG066444NIA NIH HHS P30 AG072980NIA NIH HHS P50 AG005681NIA NIH HHS R01 AG031581NIA NIH HHS R01 AG043434NIA NIH HHS R01 AG069453NIA NIH HHS RF1 AG073424NIBIB NIH HHS R01 EB009352NIH HHS S10 OD025214NINDS NIH HHS P30 NS098577
6 · The paper itself

Abstract

introductionMultiple positron emission tomography (PET) tracers are available for amyloid imaging, posing a significant challenge to consensus interpretation and quantitative analysis. We accordingly developed and validated a deep learning model as a harmonization strategy.

methodA Residual Inception Encoder-Decoder Neural Network was developed to harmonize images between amyloid PET image pairs made with Pittsburgh Compound-B and florbetapir tracers. The model was trained using a dataset with 92 subjects with 10-fold cross validation and its generalizability was further examined using an independent external dataset of 46 subjects.

resultsSignificantly stronger between-tracer correlations (P < .001) were observed after harmonization for both global amyloid burden indices and voxel-wise measurements in the training cohort and the external testing cohort. DISCUSSION: We proposed and validated a novel encoder-decoder based deep model to harmonize amyloid PET imaging data from different tracers. Further investigation is ongoing to improve the model and apply to additional tracers.

Indexed as

Alzheimer DiseaseBrainAmyloidAmyloidogenic ProteinsAniline CompoundsHumansPositron-Emission TomographyRadiopharmaceuticalsAmyloidAmyloidogenic ProteinsAniline CompoundsRadiopharmaceuticalsAlzheimer's diseaseamyloid PETCentiloid

Identifiers

PMID35142053
PMCPMC9360199

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.