ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2022
Slowing gait speed precedes cognitive decline by several years.
Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 4 of them syntheses that pooled it.
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Who cites it
63 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Motor performance and its association with Alzheimer's-related biomarkers: a systematic review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Pooled it
- Advances in gait research related to Alzheimer's disease.Frontiers in neurology · 2025Pooled it
- Sarcopenia screening based on the assessment of gait with inertial measurement units: a systematic review.BMC geriatrics · 2024Pooled it
- Early detection of diseases causing dementia using digital navigation and gait measures: A systematic review of evidence.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2024Pooled it
- Effect of Dual-task Exercise on Cognition and Dual-task Cost in the Elderly with Mild Cognitive Impairment: A Randomized Pilot Study.CNS & neurological disorders drug targets · 2026Trial
- Enhancing Neurocognitive Health via Activity, Nutrition and Cognitive Exercise (ENHANCE): A Randomized Controlled Trial.Journal of cachexia, sarcopenia and muscle · 2025Trial
- Association of tongue, handgrip, and pinch strength with blood-based phosphorylated-tau 181 in cognitively healthy older adults.GeroScience · 2026Article
- Sensorimotor function as an early marker of cognitive decline and alzheimer's biomarker burden.GeroScience · 2026Article
- Potential Indicators of Transition to Cognitive Decline in Older Men: A Longitudinal Analysis of Multiple Sensory, Balance, and Gait Changes.Diagnostics (Basel, Switzerland) · 2026Article
- Association Between Smartphone-Based IMU Turning Performance and Screening-Defined Mild Cognitive Impairment in Older Adults.Sensors (Basel, Switzerland) · 2026Article
- Movement Performance is Associated With Dementia in Older Women: A 20 Year Longitudinal Study Using Optoelectronic Kinesiology.Mayo Clinic proceedings. Digital health · 2026Article
- Turning as a single and dual task-associations with Alzheimer's and vascular pathologies in cognitively healthy older people.The journals of gerontology. Series A, Biological sciences and medical sciences · 2026Article
- Dietary diversity, multidimensional gait characteristics, and related biomarkers in older adults: a wearable sensors study.The journal of nutrition, health & aging · 2026Article
- Trajectories of frailty, grip strength and gait speed preceding dementia: a nested case-control study.Age and ageing · 2026Article
- Early Microstructural Changes in the Left Inferior Fronto-Occipital Fasciculus: A Key Factor in Probable Alzheimer's Disease Patients With Slow Gait Speed.Brain and behavior · 2026Article
- Immediate and Long-Term Effectiveness of a Therapeutic Exercise Protocol in Patients with Dementia.Journal of clinical medicine · 2026Article
- Falls predict faster progression to Alzheimer's dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Cognitive Impairment Is Associated with Disrupted Motor Planning in Older Adults.Neuro-degenerative diseases · 2026Article
- Brain over muscle: central mechanisms predominate in gait impairment among older adults with type 2 diabetes mellitus.Frontiers in aging neuroscience · 2026Article
- Differential Associations Between Distinct Components of Cognitive and Physical Function in Middle-Aged and Older Adults.Brain sciences · 2025Article
3 more citing papers are in PubMed but not listed here.
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Authors and funding
12 authors.
Funding
Abstract
introductionIn this longitudinal study, we aimed to examine if slowing gait speed preceded cognitive decline and correlated with brain amyloidosis.
methodsThe sample (n = 287) was derived from the Gothenburg H70 Birth Cohort Studies, with follow-ups between 2000 and 2015. Gait speed was measured by indoor walk, and cognition using the Clinical Dementia Rating (CDR) score. All participants had CDR = 0 at baseline. Some participants had data on cerebrospinal fluid (CSF) amyloid beta (Aβ)
resultsGait speed for participants who worsened in CDR score during follow-up was slower at most examinations. Baseline gait speed could significantly predict CDR change from baseline to follow-up. Subjects with pathological CSF Aβ DISCUSSION: Our results indicate that gait speed decline precedes cognitive decline, is linked to Alzheimer's pathology, and might be used for early detection of increased risk for dementia development.
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