ArticleHuman brain mapping2022
Tractostorm 2: Optimizing tractography dissection reproducibility with segmentation protocol dissemination.
Article in Human brain mapping, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
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Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- A systematic review of automated methods to perform white matter tract segmentation.Frontiers in neuroscience · 2024Pooled it
- Mapping Caudolenticular Gray Matter Bridges in the Human Brain Striatum Through Diffusion Magnetic Resonance Imaging and Tractography.Human brain mapping · 2025Article
- Sex-related variability of white matter tracts in the whole HCP cohort.Brain structure & function · 2024Article
- Multimodal study of multilevel pulvino-temporal connections: a new piece in the puzzle of lexical retrieval networks.Brain : a journal of neurology · 2024Article
- Bounding tractogram redundancy.Frontiers in neuroscience · 2024Article
- High-frequency longitudinal white matter diffusion- and myelin-based MRI database: Reliability and variability.Human brain mapping · 2023Article
- The influence of regions of interest on tractography virtual dissection protocols: general principles to learn and to follow.Brain structure & function · 2022Article
- Tractostorm 2: Optimizing tractography dissection reproducibility with segmentation protocol dissemination.Human brain mapping · 2022Article
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Authors and funding
26 authors at 7 institutions in 5 countries.
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Abstract
The segmentation of brain structures is a key component of many neuroimaging studies. Consistent anatomical definitions are crucial to ensure consensus on the position and shape of brain structures, but segmentations are prone to variation in their interpretation and execution. White-matter (WM) pathways are global structures of the brain defined by local landmarks, which leads to anatomical definitions being difficult to convey, learn, or teach. Moreover, the complex shape of WM pathways and their representation using tractography (streamlines) make the design and evaluation of dissection protocols difficult and time-consuming. The first iteration of Tractostorm quantified the variability of a pyramidal tract dissection protocol and compared results between experts in neuroanatomy and nonexperts. Despite virtual dissection being used for decades, in-depth investigations of how learning or practicing such protocols impact dissection results are nonexistent. To begin to fill the gap, we evaluate an online educational tractography course and investigate the impact learning and practicing a dissection protocol has on interrater (groupwise) reproducibility. To generate the required data to quantify reproducibility across raters and time, 20 independent raters performed dissections of three bundles of interest on five Human Connectome Project subjects, each with four timepoints. Our investigation shows that the dissection protocol in conjunction with an online course achieves a high level of reproducibility (between 0.85 and 0.90 for the voxel-based Dice score) for the three bundles of interest and remains stable over time (repetition of the protocol). Suggesting that once raters are familiar with the software and tasks at hand, their interpretation and execution at the group level do not drastically vary. When compared to previous work that used a different method of communication for the protocol, our results show that incorporating a virtual educational session increased reproducibility. Insights from this work may be used to improve the future design of WM pathway dissection protocols and to further inform neuroanatomical definitions.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.