Evidence map›Paper›PMID 35141979›Full record

ReviewNMR in biomedicine2023

Detection of tissue pH with quantitative chemical exchange saturation transfer magnetic resonance imaging.

Takahiro Igarashi, Hahnsung Kim, Phillip Zhe Sun

Open access · greenAbstract readReview
In one paragraph

Review in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
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  10. Review
  11. Quasi-steady-state (QUASS) reconstruction enhances TMagnetic resonance in medicine · 2024
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Development of a Synthetic Biosensor for Chemical Exchange MRI UtilizingbioRxiv : the preprint server for biology · 2023
    Article
  17. Article
  18. Imaging in translational cancer research.Cancer biology & medicine · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 2 countries.

Takahiro IgarashiAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Hahnsung KimDepartment of Radiology and Imaging Sciences, Emory University School of Medicine, Atlanta, Georgia, USA.
Phillip Zhe SunAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Harvard Medical School, Charlestown, Massachusetts, USA.
Emory University · USImaging Center · USMassachusetts General Hospital · US

Funding

Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0M
Establishment of fast pH MRI for imaging metabolic injury during acute strokeR01NS083654 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI Phillip Zhe Sun · 2013 to 2026
$4.0M
NIH HHS P51 OD011132NINDS NIH HHS R01 NS083654
6 · The paper itself

Abstract

Chemical exchange saturation transfer (CEST) magnetic resonance imaging (MRI) has emerged as a novel means for sensitive detection of dilute labile protons and chemical exchange rates. By sensitizing to pH-dependent chemical exchange, CEST MRI has shown promising results in monitoring tissue statuses such as pH changes in disorders like acute stroke, tumor, and acute kidney injury. This article briefly reviews the basic principles for CEST imaging and quantitative measures, from the simplistic asymmetry analysis to multipool Lorentzian decoupling and quasi-steady-state reconstruction. In particular, the advantages and limitations of commonly used quantitative approaches for CEST applications are discussed.

Indexed as

Image Interpretation, Computer-AssistedStrokeHumansHydrogen-Ion ConcentrationMagnetic Resonance ImagingPhantoms, ImagingProtonsProtonsacute strokeamide proton transferchemical exchange saturation transferpHpH-weightedtumor

Identifiers

PMID35141979
PMCPMC10249910
OpenAlexW4211249944

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.