ArticleCell proliferation2022
Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health.
Article in Cell proliferation, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.
- Revealing the molecular landscape of human placenta: a systematic review and meta-analysis of single-cell RNA sequencing studies.Human reproduction update · 2024Pooled it
- A FOS/NFKB1-associated Hofbauer cell subset mediates placental niche dysregulation in early-onset fetal growth restriction.Frontiers in cell and developmental biology · 2026Article
- Shedding Light on the COVID-19 Pandemic: Placental Expression of Cell Biomarkers in Negative, Vaccinated, and Positive Pregnant Women.Journal of clinical medicine · 2024Article
- Immune rebalancing at the maternal-fetal interface of maternal SARS-CoV-2 infection during early pregnancy.Protein & cell · 2024Article
- Acute placental insufficiency two weeks after an asymptomatic COVID-19 maternal infection: the deleterious effects of the SARS-CoV-2 placentitis.Archives of gynecology and obstetrics · 2024Article
- A review of single-cell transcriptomics and epigenomics studies in maternal and child health.Epigenomics · 2024Review
- Endocytosis at the maternal-fetal interface: balancing nutrient transport and pathogen defense.Frontiers in immunology · 2024Review
- Genome-wide identification of transcriptional enhancers during human placental development and association with function, differentiation, and disease†.Biology of reproduction · 2023Article
- Placental single cell transcriptomics: Opportunities for endocrine disrupting chemical toxicology.Molecular and cellular endocrinology · 2023Article
- SARS-CoV-2 niches in human placenta revealed by spatial transcriptomics.Med (New York, N.Y.) · 2023Article
- Cellular and Molecular Atlas of Peripheral Blood Mononuclear Cells from a Pregnant Woman After Recovery from COVID-19.Maternal-fetal medicine (Wolters Kluwer Health, Inc.) · 2023Article
- Article
- Immune repertoire analysis of normal Chinese donors at different ages.Cell proliferation · 2022Article
- Single-Cell Immunobiology of the Maternal-Fetal Interface.Journal of immunology (Baltimore, Md. : 1950) · 2022Review
- The COVID-19 Pandemic and Pregnancy: Impact on Mothers and Newborns.Seminars in pediatric neurology · 2022Review
- Cellular and molecular atlas of the placenta from a COVID-19 pregnant woman infected at midgestation highlights the defective impacts on foetal health.Cell proliferation · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
29 authors at 6 institutions in 2 countries.
Funding
Abstract
objectivesThe impacts of the current COVID-19 pandemic on maternal and foetal health are enormous and of serious concern. However, the influence of SARS-CoV-2 infection at early-to-mid gestation on maternal and foetal health remains unclear. MATERIALS AND
methodsHere, we report the follow-up study of a pregnant woman of her whole infective course of SARS-CoV-2, from asymptomatic infection at gestational week 20 to mild and then severe illness state, and finally cured at Week 24. Following caesarean section due to incomplete uterine rupture at Week 28, histological examinations on the placenta and foetal tissues as well as single-cell RNA sequencing (scRNA-seq) for the placenta were performed.
resultsCompared with the gestational age-matched control placentas, the placenta from this COVID-19 case exhibited more syncytial knots and lowered expression of syncytiotrophoblast-related genes. The scRNA-seq analysis demonstrated impaired trophoblast differentiation, activation of antiviral and inflammatory CD8 T cells, as well as the tight association of increased inflammatory responses in the placenta with complement over-activation in macrophages. In addition, levels of several inflammatory factors increased in the placenta and foetal blood.
conclusionThese findings illustrate a systematic cellular and molecular signature of placental insufficiency and immune activation at the maternal-foetal interface that may be attributed to SARS-CoV-2 infection at the midgestation stage, which highly suggests the extensive care for maternal and foetal outcomes in pregnant women suffering from COVID-19.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.