ReviewCurrent oncology reports2022
Central Nervous System Involvement in Adults with Acute Leukemia: Diagnosis, Prevention, and Management.
Review in Current oncology reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06175702 (Treatment Protocol for Newky Diagnosed Adult Ph-Chromosome Positive), which is not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment Protocol for Newky Diagnosed Adult Ph-Chromosome Positive (BCR::ABL1) Acute Lymphoblastic Leukemia (LALPh2022)
Who cites it
34 citing papers in PubMed, 44 citations in OpenAlex.
- Molecular characterization and predictors of relapse in patients with Ph + ALL after frontline ponatinib and blinatumomab.Journal of hematology & oncology · 2025Trial
- Best evidence summary of dietary management during chemotherapy in children with acute lymphoblastic leukemia.Asia-Pacific journal of oncology nursing · 2026Review
- Protocol for cerebrospinal fluid analysis using enrichment-enhanced surface-enhanced Raman spectroscopy and transformer-enabled spectral classification.STAR protocols · 2026Article
- Central nervous system penetration of imatinib in acute lymphoblastic leukemia: Pharmacokinetic analysis and clinical implications.Cancer chemotherapy and pharmacology · 2026Article
- MSLN expression predicts a high risk of EMD in AML by promoting cell adhesion and metastasis via interaction with MUC16.Blood advances · 2026Article
- Central Nervous System Involvement in Acute Myeloid Leukemia: From Pathophysiology to Neuroradiologic Features and the Emerging Role of Artificial Intelligence.Journal of clinical medicine · 2026Review
- The combination of alternating reduced-dose blinatumomab and hyper-CVAD as consolidation therapy in patients with newly-diagnosed adult B-cell acute lymphoblastic leukemia.Therapeutic advances in hematology · 2026Article
- Case Report: Optic nerve infiltration associated with sequential CRVO and CRAO in isolated CNS relapse of AML.Frontiers in medicine · 2026Article
- The double-edged role of SPAG6 in male reproductive toxicity: pro-invasive in leukemia, protective in germ cells.Frontiers in medicine · 2026Article
- Case Report: Central nervous system infiltration after allogeneic hematopoietic stem cell transplantation in high-risk myelodysplastic neoplasms.Frontiers in oncology · 2026Article
- Rapid and sensitive acute leukemia classification and diagnosis platform using deep learning-assisted SERS detection.Cell reports. Medicine · 2025Article
- A Sudden Expansion: Acute Subdural Hematoma From Extramedullary Acute Myeloid Leukemia.Cureus · 2025Article
- Ophthalmic Manifestations Revealing Neurological Relapse in T-cell Acute Lymphoblastic Leukemia: A Case Report.Cureus · 2025Article
- The contemporary spectrum of radiotherapy for hematologic malignancies involving the central nervous system: From focal therapy to craniospinal.Seminars in radiation oncology · 2025Review
- Therapeutics of acute myeloid leukemia with central nervous system involvement.Clinical hematology international · 2025Article
- Adult-onset Still's disease presenting with aseptic meningitis: a case report.Frontiers in immunology · 2025Article
- Isolated central nervous system relapse in acute myeloid leukemia: a case report and review of therapeutic challenges.Frontiers in oncology · 2025Article
- Clinical data and MRI features-based nomogram for differentiation of central nervous system infection and central nervous system involvement in hematological malignancy.Annals of hematology · 2024Article
- Routes and molecular mechanisms of central nervous system involvement in acute myeloid leukemia (Review).Oncology reports · 2024Review
- Myeloid Sarcoma: Novel Advances Regarding Molecular Pathogenesis, Presentation and Therapeutic Options.Journal of clinical medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purpose of reviewRecent treatment advances in both acute myeloid leukemia and acute lymphoblastic leukemia have drastically improved outcomes for these diseases, but central nervous system (CNS) relapses still occur. Treatment of CNS disease can be challenging due to the impermeability of the blood-brain barrier to many systemic therapies. RECENT
findingsThe diagnosis of CNS leukemia relies on assessment of clinical symptoms, cerebrospinal fluid sampling for conventional cytology and/or flow cytometry, and neuroimaging. While treatment of CNS leukemia with systemic or intrathecal chemotherapy and/or radiation can be curative in some patients, these modalities can also lead to serious toxicities. In the modern era, prophylaxis with intrathecal chemotherapy is the most important strategy to prevent CNS relapses in high risk patients. Accurate risk stratification tools and the use of risk-adapted prophylactic therapy are imperative to improving the outcomes of patients with acute leukemias and preventing the development of CNS leukemia.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.