ArticleEuropean radiology experimental2022
The impact of imaging time and contrast agent dose on screening for osteoporosis with contrast-enhanced CT.
Article in European radiology experimental, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- Effects of contrast on opportunistic computed tomography vertebral bone mineral density analysis using internal calibration.JBMR plus · 2026Article
- Advances in Imaging-Based Fracture Risk Assessment for Unlocking Latent Skeletal Fragility.Current osteoporosis reports · 2026Review
- Opportunistic osteoporosis assessment from routine CT-effect of intravenous contrast agents on absolute values, T-scores, and derived classifications in single- and dual-energy CT.European radiology · 2026Article
- Opportunistic osteoporosis screening using multiphase abdominal CT: reliable proximal femur BMD assessment with AI-assisted segmentation.Frontiers in medicine · 2026Article
- Breaking the silence: AI's contribution to detecting vertebral fractures in opportunistic CT scans in the elderly-a validation study.Archives of osteoporosis · 2025Article
- Effect of contrast media on CT bone density assessment: comparative analysis of low-dose chest CT and abdominopelvic CT.Scientific reports · 2024Article
- Using QCT for the prediction of spontaneous age- and gender-specific thoracolumbar vertebral fractures and accompanying distant vertebral fractures.BMC musculoskeletal disorders · 2024Article
- Evaluation of deep learning-based quantitative computed tomography for opportunistic osteoporosis screening.Scientific reports · 2024Article
- Addressing Challenges of Opportunistic Computed Tomography Bone Mineral Density Analysis.Diagnostics (Basel, Switzerland) · 2023Review
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3 authors at 1 institution in 1 country.
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Abstract
backgroundScreening for osteoporosis with contrast-enhanced computed tomography (CT) is promising for identifying high-risk osteoporotic patients. Our aims were (1) to investigate the estimated volume bone mineral density (vBMD) change over time after contrast injection (CT perfusion imaging, CTPI); and (2) to examine the influence of contrast dose on vBMD.
methodsFifteen patients, aged 71 ± 9 years (mean ± standard deviation, range 55-86) underwent a CTPI examination (28 scans within 63 s) of the upper body followed (after a waiting time of 10 min) by a full 4-phase CT examination (4 scans within 4 min). The contrast dose for CTPI was 0.38-0.83 mL/kg, and for 4-phase CT was 0.87-1.29 mL/kg. Vertebrae L1-L3 were analysed totalling 43 vertebrae, using Mindways qCT Pro.
resultsAfter contrast injection, vBMD showed a near-horizontal line until 17.5 s (non-contrast phase), followed by a steep increase 17.5-41.5 s after contrast injection, i.e., in the arterial phase, which plateaued 41.5 s after, i.e., in the early venous phase. A higher contrast dose per kg yielded significantly higher vBMD increase in both the arterial and venous phase (p < 0.003).
conclusionsBoth time from contrast administration and contrast dose per kg affected vBMD results. In arterial phase, the steepness of the curve makes vBMD estimation unsure. However, as values plateaued in the venous phase it might be possible to predict the correct vBMD values. Furthermore, contrast dose is a factor that needs to be adjusted for when using such a formula.
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