Evidence map›Paper›PMID 35141812›Full record

ArticleSleep & breathing = Schlaf & Atmung2023

Obstructive sleep apnea is not associated with diabetic retinopathy in diabetes: a prospective case-control study.

Hind El Ouardighi, Kris G Poppe, Pierre Kleynen, Lidia Grabzcan, Flora Veltri, Anne Violette Bruyneel, Pham Anh Hong Nguyen, Marie Bruyneel

Abstract read
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In one paragraph

Article in Sleep & breathing = Schlaf & Atmung, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 7 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Hind El OuardighiDepartment of Ophthalmology, CHU Saint-Pierre, Brussels, Belgium.
Kris G PoppeUniversité Libre de Bruxelles (ULB), Brussels, Belgium.
Pierre KleynenUniversité Libre de Bruxelles (ULB), Brussels, Belgium.
Lidia GrabzcanUniversité Libre de Bruxelles (ULB), Brussels, Belgium.
Flora VeltriUniversité Libre de Bruxelles (ULB), Brussels, Belgium.
Anne Violette BruyneelGeneva School of Health Sciences, HES-SO University of Applied Sciences and Arts Western Switzerland, Geneva, Switzerland.
Pham Anh Hong NguyenChest Service, CHU Saint-Pierre Rue Haute, 322, 1000, Brussels, Belgium.
Marie BruyneelUniversité Libre de Bruxelles (ULB), Brussels, Belgium. Marie_Bruyneel@stpierre-bru.be.ORCID 0000-0002-7035-1266
Université Libre de Bruxelles · BECentre Hospitalier Universitaire de Saint-Pierre · BEHES-SO University of Applied Sciences and Arts Western Switzerland · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDiabetic retinopathy (DR) is the most common ocular complication of type 2 diabetes mellitus (T2D) and is associated with diabetes duration, glycemic control, and hypertension (HTN). Obstructive sleep apnea (OSA) is frequent in T2D and is associated with poor glycemic control. However, it is unclear if there is an association between OSA and DR. This study aimed to assess whether or not the presence of OSA in patients with T2D was associated with DR.

methodsIn this prospective case-control study, consecutive patients with DM attending the ophthalmology clinics were recruited to include patients with DR (cases) and without DR (controls). OSA was diagnosed by attended polysomnography (PSG). Blood pressure and a fasting morning blood sample, including glycosylated hemoglobin (HbA1c), were recorded. Patients were matched for age, body mass index (BMI), gender, and T2D duration.

resultsThirty diabetic patients with DR were matched with 30 controls. In all patients, the prevalence of moderate-to-severe OSA was 57%. In the logistic regression analysis, DR was associated with increased HbA1c (OR 2.63, 95% CI 1.35-5.16, p = 0.004) but not with any PSG parameter. In the DR group, PSG parameters were not associated with the severity of ocular disease (non-proliferative, proliferative, presence/absence of macular edema). The proliferative aspect of DR was correlated with age (p = 0.017). DR occurred more frequently in uncontrolled diabetes compared to well-controlled diabetes (80% vs 38%, p = 0.029).

conclusionsIn patients with T2D, the presence of DR is not associated with OSA, but with poorly controlled T2D.

Indexed as

Diabetes Mellitus, Type 2Diabetic RetinopathySleep Apnea, ObstructiveCase-Control StudiesGlycated HemoglobinHumansGlycated HemoglobinBody mass indexDiabetes mellitusDiabetic retinopathyGlycosylated hemoglobinObstructive sleep apnea

Identifiers

PMID35141812
OpenAlexW4210869838

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.