Evidence map›Paper›PMID 35141614›Full record

ArticleNorth American Spine Society journal2021

Vancomycin-impregnated calcium sulfate beads compared with vancomycin powder in adult spinal deformity patients undergoing thoracolumbar fusion.

Grace Xiong, Harold Fogel, Daniel Tobert, Thomas Cha, Joseph Schwab, Christopher Bono, Stuart Hershman

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in North American Spine Society journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Grace XiongHarvard Combined Orthopaedic Residency Program, Boston, MA, United States.
Harold FogelSpine Surgery and Complex Spinal Reconstruction, Massachusetts General Hospital, Harvard Medical School, Dept of Orthopaedic Surgery, Yawkey 3A, 55 Fruit St., Boston, MA 02114, United States.
Daniel TobertSpine Surgery and Complex Spinal Reconstruction, Massachusetts General Hospital, Harvard Medical School, Dept of Orthopaedic Surgery, Yawkey 3A, 55 Fruit St., Boston, MA 02114, United States.
Thomas ChaSpine Surgery and Complex Spinal Reconstruction, Massachusetts General Hospital, Harvard Medical School, Dept of Orthopaedic Surgery, Yawkey 3A, 55 Fruit St., Boston, MA 02114, United States.
Joseph SchwabSpine Surgery and Complex Spinal Reconstruction, Massachusetts General Hospital, Harvard Medical School, Dept of Orthopaedic Surgery, Yawkey 3A, 55 Fruit St., Boston, MA 02114, United States.
Christopher BonoSpine Surgery and Complex Spinal Reconstruction, Massachusetts General Hospital, Harvard Medical School, Dept of Orthopaedic Surgery, Yawkey 3A, 55 Fruit St., Boston, MA 02114, United States.
Stuart HershmanSpine Surgery and Complex Spinal Reconstruction, Massachusetts General Hospital, Harvard Medical School, Dept of Orthopaedic Surgery, Yawkey 3A, 55 Fruit St., Boston, MA 02114, United States.
Harvard University · USHarvard Affiliated Emergency Medicine Residency · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAdult spinal deformity (ASD) surgery patients are at higher risk for surgical site infections (SSIs) due to large incisions, high blood loss, long surgical duration, and extensive instrumentation. The use of vancomycin powder has demonstrated inconsistent results in ASD surgery. Antibiotic-impregnated calcium sulfate beads have been used in arthroplasty and foot and ankle surgery with promising results. The purpose of this study was to provide preliminary data on the use of vancomycin-impregnated calcium sulfate beads in the prevention of SSI following ASD surgery and provide comparisons to the use of vancomycin powder.

methodsA retrospective chart review was performed for 95 consecutive surgical ASD patients at a tertiary care center from January 2017 until March 2020. Patients received either vancomycin powder (powder group) or vancomycin-impregnated calcium sulfate beads (bead group) intrawound prior to closure. Patient demographics, operative course, and incidence of postoperative infections were recorded. A two-tailed chi-squared test was performed to compare infection rates.

resultsNinety-five patients were included for review. Forty-two patients were in the powder group and 53 patients were in the bead group. The bead group was older (59.8 vs 67.8 years,

conclusionPreliminary examination of the use of vancomycin-impregnated calcium sulfate beads demonstrated a 1.9% surgical site infection rate in adult spinal deformity surgical patients, which was not significantly different compared with the 9.5% infection rate in patients who received vancomycin powder. Prospective study is needed to determine if the differences found are significant in a larger number of patients.

Indexed as

Calcium sulfateInfectionThoracolumbar deformity

Identifiers

PMID35141614
PMCPMC8819864
OpenAlexW3115370911

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.