ArticleNorth American Spine Society journal2020
A prospective, single arm study of intraosseous basivertebral nerve ablation for the treatment of chronic low back pain: 12-month results.
Article in North American Spine Society journal, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT05207813 (A Prospective, Open-Label, Single-Arm Study of Intraosseous Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain Long-term Follow Up), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Open-Label, Single-Arm Study of Intraosseous Basivertebral Nerve Ablation for the Treatment of Chronic Low Back Pain Long-term Follow Up
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- The Effectiveness of Intraosseous Basivertebral Nerve Radiofrequency Ablation for the Treatment of Vertebrogenic Low Back Pain: An Updated Systematic Review with Single-Arm Meta-analysis.Pain medicine (Malden, Mass.) · 2022Pooled it
- Vertebrogenic Low Back Pain and Basivertebral Nerve Ablation: A Review of Mechanisms, Imaging-Driven Selection, and Clinical Outcomes.Diagnostics (Basel, Switzerland) · 2026Review
- The utility of SPECT-CT in identifying vertebral endplate changes for basivertebral nerve ablation: A retrospective study with MRI comparison.Interventional pain medicine · 2026Article
- Modic changes and their role in vertebrogenic back pain: a literature review.Skeletal radiology · 2026Review
- Synergistic Effects of Basivertebral Nerve Ablation Plus Schroth Therapy for Adult Scoliosis: A Multicenter Propensity-Matched Cohort Study.Pain and therapy · 2025Article
- Rates of lumbar vertebral body compression fracture after basivertebral nerve ablation: A retrospective study utilizing a large national database.Interventional pain medicine · 2025Article
- Patient selection, clinical outcomes, associated healthcare utilization, and cost-effectiveness of basivertebral nerve ablation for the treatment of vertebrogenic low back pain: A narrative review.North American Spine Society journal · 2025Article
- Modic Changes as Biomarkers for Treatment of Chronic Low Back Pain.Biomedicines · 2025Review
- Decrease in opioid use and spinal interventions after basivertebral nerve ablation.Interventional pain medicine · 2025Article
- Advances in Basivertebral Nerve Ablation for Chronic Low Back Pain: A Narrative Review.Journal of personalized medicine · 2025Review
- Intraosseous basivertebral nerve ablation: A 5-year pooled analysis from three prospective clinical trials.Interventional pain medicine · 2024Article
- Basivertebral Nerve Ablation for Treatment of Lower Back Pain.Biomedicines · 2024Review
- Low back pain-related healthcare utilization following intraosseous basivertebral nerve radiofrequency ablation: a pooled analysis from three prospective clinical trials.Pain medicine (Malden, Mass.) · 2024Article
- Computed Tomographic Characterization for Basivertebral Nerve Ablation Utilizing a Radiofrequency Multitined Expandable Electrode.Medical devices (Auckland, N.Z.) · 2024Article
- Intraosseous basivertebral nerve ablation: Pooled long-term outcomes from two prospective clinical trials.Interventional pain medicine · 2023Article
- Modic changes as seen on MRI are associated with nonspecific chronic lower back pain and disability.Journal of orthopaedic surgery and research · 2023Review
- Review
- ISASS Policy Statement 2022: Literature Review of Intraosseous Basivertebral Nerve Ablation.International journal of spine surgery · 2022Article
- Pain Location and Exacerbating Activities Associated with Treatment Success Following Basivertebral Nerve Ablation: An Aggregated Cohort Study of Multicenter Prospective Clinical Trial Data.Pain medicine (Malden, Mass.) · 2022Article
- The Relationship Between Patient Demographic and Clinical Characteristics and Successful Treatment Outcomes After Basivertebral Nerve Radiofrequency Ablation: A Pooled Cohort Study of Three Prospective Clinical Trials.Pain medicine (Malden, Mass.) · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The basivertebral nerve (BVN) has been a recently discovered target as a potential source for vertebrogenic chronic low back pain (CLBP). Prior randomized controlled trials have demonstrated safety and efficacy of BVN ablation for vertebrogenic CLBP, but minimal data exists regarding BVN ablation's clinical effectiveness with broader application outside of strict trial inclusion criteria. Methods: Prospective, single arm, open label effectiveness trial of 48 patients from community spine and pain practices treated with BVN ablation. Inclusion criteria required more than 6 months of CLBP and type 1 or 2 Modic changes on MRI to be enrolled. Patients were followed post procedure for 12 months using ODI, VAS, EQ-5D-5L and SF-36 patient reported outcome metrics.Results: 47 patients successfully received BVN ablation and 45 patients completed 12 months of follow up. Mean reduction in ODI at 12 months was 32.31 +/- 14.07 (p<0.001) with 88.89% (40/45) patients reporting a ≥15 point ODI decrease at 12 months. Mean VAS pain score decrease was 4.31+/-2.51 at 12 months (p<0.001) and more than 69% reported a 50% reduction in VAS pain scale. Similarly, SF-36 and EQ-5D-5L scores improved 26.27+/-17.19 and 0.22+/-0.15 (each p<0.001). Conclusions: This data supports the clinical effectiveness of BVN ablation in the community practice setting, with similar 12 month improvements in patient reported outcomes as seen in previously published randomized control trials.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.