Evidence map›Paper›PMID 35141570›Full record

ReviewJVS-vascular science2022

β-Aminopropionitrile-induced aortic aneurysm and dissection in mice.

Hisashi Sawada, Zachary A Beckner, Sohei Ito, Alan Daugherty, Hong S Lu

Open access · goldAbstract readReview
In one paragraph

Review in JVS-vascular science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
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  5. Aortotomy-induced acute mural thrombosis progresses to saccular aneurysm formation.Research and practice in thrombosis and haemostasis · 2026
    Article
  6. Article
  7. Article
  8. Article
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  10. Article
  11. [Research progress on the role of ferroptosis in aortic dissection].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2024
    Review
  12. Article
  13. Article
  14. Article
  15. Angiotensinogen as a Therapeutic Target for Cardiovascular and Metabolic Diseases.Arteriosclerosis, thrombosis, and vascular biology · 2024
    Review
  16. Article
  17. Article
  18. Article
  19. Frontiers in cardiovascular medicine · 2023
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hisashi SawadaSaha Cardiovascular Research Center, University of Kentucky, Lexington, Ky.
Zachary A BecknerSaha Cardiovascular Research Center, University of Kentucky, Lexington, Ky.
Sohei ItoSaha Cardiovascular Research Center, University of Kentucky, Lexington, Ky.
Alan DaughertySaha Cardiovascular Research Center, University of Kentucky, Lexington, Ky.
Hong S LuSaha Cardiovascular Research Center, University of Kentucky, Lexington, Ky.
University of Kentucky · US

Funding

Determinants of Aorta HeterogeneityR35HL155649 · NHLBI · UNIVERSITY OF KENTUCKY · PI Alan Daugherty · 2021 to 2026
$5.3M
Adventitial-medial interactions in thoracic aortic diseasesR01HL133723 · NHLBI · UNIVERSITY OF KENTUCKY · PI DAUGHERTY, ALAN · 2016 to 2019
$2.9M
NHLBI NIH HHS R01 HL133723NHLBI NIH HHS R35 HL155649
6 · The paper itself

Abstract

The mechanistic basis for the formation of aortic aneurysms and dissection needs to be elucidated to facilitate the development of effective medications. β-Aminopropionitrile administration in mice has been used frequently to study the pathologic features and mechanisms of aortic aneurysm and dissection. This mouse model mimics several facets of the pathology of human aortic aneurysms and dissection, although many variables exist in the experimental design and protocols that must be resolved to determine its application to the human disease. In the present brief review, we have introduced the development of this mouse model and provided insights into understanding its pathologic features.

Indexed as

Aortic aneurysmsAortic dissectionMouseβ-Aminopropionitrile

Identifiers

PMID35141570
PMCPMC8814647
OpenAlexW4205884161

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.