Evidence map›Paper›PMID 35141563›Full record

ArticleSTAR protocols2022

A protocol for investigating lipidomic dysregulation and discovering lipid biomarkers from human serums.

Moran Chen, Yanhong Hao, Suming Chen

Abstract read
In one paragraph

Article in STAR protocols, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Moran ChenThe Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, China.
Yanhong HaoThe Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, China.
Suming ChenThe Institute for Advanced Studies, Wuhan University, Wuhan, Hubei 430072, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Lipids play important roles in various human diseases. Disease-associated lipid dysregulation and biomarkers could provide molecular clues for diagnosis, pathogenesis, and therapy. This protocol provides a step-by-step workflow to investigate lipid dysregulation and discover biomarkers in human serum samples by liquid chromatography-mass spectrometry (LC-MS)-based lipidomics and machine learning analysis. The workflow includes project design, serum collection, sample preparation, data acquisition, data processing, and machine learning analysis. For complete details on the use and execution of this profile, please refer to Hao et al. (2021).

Indexed as

LipidomicsLipidsBiomarkersChromatography, LiquidHumansMass SpectrometryBiomarkersLipidsBioinformaticsBiotechnology and bioengineeringClinical ProtocolHealth SciencesMass SpectrometryMetabolism

Identifiers

PMID35141563
PMCPMC8814823

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.