Evidence map›Paper›PMID 35141527›Full record

ArticleCritical care explorations2022

Concomitant Sepsis Diagnoses in Acute Myocardial Infarction-Cardiogenic Shock: 15-Year National Temporal Trends, Management, and Outcomes.

Jacob C Jentzer, Anusha G Bhat, Sri Harsha Patlolla, Shashank S Sinha, P Elliott Miller, Patrick R Lawler, Sean van Diepen, Ashish K Khanna, David X Zhao, Saraschandra Vallabhajosyula

Open access · goldAbstract read
In one paragraph

Article in Critical care explorations, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
8.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 32 citations in OpenAlex.

  1. Observational
  2. Article
  3. Article
  4. Article
  5. Interleukin-6 in Cardiogenic Shock.Current cardiology reports · 2025
    Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
  17. Review
  18. Article
  19. [Analysis of the unicentric registry of the Infarction Code program: retrospective cohort].Revista medica del Instituto Mexicano del Seguro Social · 2024
    Observational
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Jacob C JentzerDepartment of Cardiovascular Medicine, Mayo Clinic, Rochester, MN.
Anusha G BhatDivision of Cardiovascular Medicine, Department of Medicine, University of Maryland, Baltimore, MD.
Sri Harsha PatlollaDepartment of Cardiovascular Surgery, Mayo Clinic, Rochester, MN.
Shashank S SinhaInova Heart and Vascular Institute, Inova Fairfax Medical Center, Falls Church, VA.
P Elliott MillerDivision of Cardiovascular Medicine, Department of Medicine, Yale University School of Medicine, New Haven, CT.
Patrick R LawlerPeter Munk Cardiac Centre, University Health Network, Toronto, ON, Canada.
Sean van DiepenDepartment of Critical Care and Division of Cardiology, Department of Medicine, University of Alberta, Edmonton, AB, Canada.
Ashish K KhannaSection on Critical Care Medicine, Department of Anesthesiology, Wake Forest University School of Medicine, Winston Salem, NC.
David X ZhaoSection of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC.
Saraschandra VallabhajosyulaSection of Cardiovascular Medicine, Department of Medicine, Wake Forest University School of Medicine, Winston Salem, NC.
Mayo Clinic in Arizona · USOutcomes Research Consortium · USUniversity Health Network · CAUniversity of Alberta · CAYale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NRSA Training CoreTL1TR001864 · NCATS · YALE UNIVERSITY · PI CANTLEY, LLOYD G, EDELMAN, E. JENNIFER · 2016 to 2025
$9.9M
Wake Forest Clinical and Translational Science AwardKL2TR001421 · NCATS · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI MILLER, DAVID P · 2015 to 2023
$5.8M
NCATS NIH HHS KL2 TR001421NCATS NIH HHS TL1 TR001864NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

objectivesMixed cardiogenic-septic shock is common and associated with high mortality. There are limited contemporary data on concomitant sepsis in acute myocardial infarction complicated by cardiogenic shock (AMI-CS).

designObservational study.

settingTwenty percent stratified sample of all community hospitals (2000-2014) in the United States.

participantsAdults (> 18 yr) with AMI-CS with and without concomitant sepsis.

interventionsNone. MEASUREMENTS AND MAIN

resultsOutcomes of interest included inhospital mortality, development of noncardiac organ failure, complications, utilization of guideline-directed procedures, length of stay, and hospitalization costs. Over 15 years, 444,253 AMI-CS admissions were identified, of which 27,057 (6%) included sepsis. The sepsis cohort had more comorbidities and had higher rates of noncardiac multiple organ failure (92% vs 69%) (all

conclusionsIn AMI-CS, concomitant sepsis is associated with higher mortality and morbidity highlighting the need for early recognition and integrated management of mixed shock.

Indexed as

acute myocardial infarctioncardiogenic shockcirculatory shockcritical care cardiologysepsis

Identifiers

PMID35141527
PMCPMC8820909
OpenAlexW4210496905

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.