Evidence map›Paper›PMID 35141505›Full record

ArticleiScience2022

Loss of physical contact in space alters the dopamine system in

Surabhi Sudevan, Kasumi Muto, Nahoko Higashitani, Toko Hashizume, Akira Higashibata, Rebecca A Ellwood, Colleen S Deane, Mizanur Rahman, Siva A Vanapalli, Timothy Etheridge and 2 more

Open access · goldAbstract read
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 22 citations in OpenAlex.

  1. Reduced Mechanical Tactile Stimulation Under Space Microgravity Affects Synaptic Signaling and Contributes to Neuromuscular Aging in Caenorhabditis elegans.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026
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  9. iScience · 2023
    Review
  10. Increased mitochondrial CaFASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2023
    Article
  11. A Compact Imaging Platform for ConductingLife (Basel, Switzerland) · 2023
    Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 6 institutions in 3 countries.

Surabhi SudevanGraduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
Kasumi MutoGraduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
Nahoko HigashitaniGraduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
Toko HashizumeAdvanced Engineering Services Co. Ltd, Tsukuba Mitsui Building7F,1-6-1 Takezono, Tsukuba, Ibaraki 305-0032, Japan.
Akira HigashibataHuman Spaceflight Technology Directorate, Japan Aerospace Exploration Agency, 2-1-1 Sengen, Tsukuba, Ibaraki 305-8505, Japan.
Rebecca A EllwoodMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby, UK.
Colleen S DeaneDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, St. Luke's Campus, Exeter, UK.
Mizanur RahmanDepartment of Chemical Engineering, Texas Tech University, Lubbock, TX, USA.
Siva A VanapalliDepartment of Chemical Engineering, Texas Tech University, Lubbock, TX, USA.
Timothy EtheridgeDepartment of Sport and Health Sciences, College of Life and Environmental Sciences, University of Exeter, St. Luke's Campus, Exeter, UK.
Nathaniel J SzewczykMedical Research Council (MRC) Versus Arthritis Centre for Musculoskeletal Ageing Research, Royal Derby Hospital, University of Nottingham, Derby, UK.
Atsushi HigashitaniGraduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
Tohoku University · JPUniversity of Nottingham · GBTexas Tech University · USUniversity of Exeter · GBAdvanced Engineering Services (Japan) · JPJapan Aerospace Exploration Agency · JP

Funding

Medical Research Council MR/T026014/1
6 · The paper itself

Abstract

Progressive neuromuscular decline in microgravity is a prominent health concern preventing interplanetary human habitation. We establish functional dopamine-mediated impairments as a consistent feature across multiple spaceflight exposures and during simulated microgravity in

Indexed as

Aerospace EngineeringSpace medicine

Identifiers

PMID35141505
PMCPMC8810405
OpenAlexW4205862783

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.