ArticleFASEB bioAdvances2022
Salivary phosphate as a biomarker for human diseases.
Article in FASEB bioAdvances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed.
- Non-invasive and user-friendly visual detection of salivary phosphate using enzymatic biosensor test strip for chronic kidney disease screening.Analytical and bioanalytical chemistry · 2026Article
- Biosensors in dental, oral and craniofacial applications.Npj biosensing · 2026Review
- Decoding E-Cigarette Secrets: Unveiling Saliva and E-Liquid Composition through Fourier-Transform Infrared Spectroscopy.ACS omega · 2025Article
- Editorial: Endocrine regulation of mineral ions and their relevance to metabolic diseases.Frontiers in endocrinology · 2024Article
- Development, Establishment, and Validation of a Model for the Mineralization of Periodontium Remodelling Cells: Cementoblasts.International journal of molecular sciences · 2023Article
- Oral manifestations of iron imbalance.Frontiers in nutrition · 2023Article
- Editorial: Nutrition and oral health: Public health relevance.Frontiers in oral health · 2023Article
- Editorial: Value-based nutritional intervention to reduce the progression of chronic human diseases.Frontiers in nutrition · 2023Article
- Phosphate Dysregulation and Metabolic Syndrome.Nutrients · 2022Article
- Salivary phosphate as a biomarker for human diseases.FASEB bioAdvances · 2022Article
- Phosphate Burden and Organ Dysfunction.Frontiers in aging · 2022Article
Corrections and comments
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Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Phosphate is a common ingredient of the daily consumed foods and is absorbed in the intestine and is excreted in the urine through the kidney to maintain the homeostatic balance. For adults, the Recommended Dietary Allowance (RDA) for phosphorus is around 700 mg/day. The change in dietary habits resulted in far more phosphate consumption (almost double) than the RDA, contributing to increased cardiovascular diseases, kidney diseases, and tumor formation. Due to a lack of clinical appreciation for the long-term consequences of chronic phosphate burden on non-communicable disorders, it is rapidly becoming a global health concern. The possible association between dysregulated phosphate metabolism and obesity is not studied in-depth, mainly because such an association is believed to be nonexistent. However, in the animal model of obesity, serum phosphate level was higher than their non-obese controls. In a similar observation line, significantly higher salivary phosphate levels were detected in obese children compared to normal-weight children. Of clinical importance, despite the significant increase of salivary phosphate levels in obese children, the plasma phosphate levels did not change in samples collected from the same group of children. Such disparity between plasma and saliva raised the possibility that human salivary phosphate levels may be an early biomarker of childhood obesity.
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Registered trials
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