ArticleAlzheimer's & dementia (Amsterdam, Netherlands)2021
Prevalent, persistent, and impairing: Longitudinal course and impact of apathy in Alzheimer's disease.
Article in Alzheimer's & dementia (Amsterdam, Netherlands), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Structural Neuroimaging Correlates of Neuropsychiatric Symptoms in Alzheimer's Disease: A Systematic Literature Review.Dementia and geriatric cognitive disorders · 2025Pooled it
- Uncovering lipid biomarkers linked to methylphenidate efficacy in treating apathy in Alzheimer's disease: insights from the ADMET 2 trial.Alzheimer's research & therapy · 2026Trial
- Trial
- Associations between apathy and global cognition in a 5-year follow-up of individuals with Alzheimer's disease.Journal of neuropsychology · 2026Article
- Psychometric Properties of the Greek Apathy Evaluation Scale Clinician Version (AES-C) in MCI Patients and Cognitively Healthy Older Adults.Behavioral sciences (Basel, Switzerland) · 2026Article
- Dopamine System Dysfunction in Alzheimer's Disease.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2025Review
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
- Psychosocial factors associated with physical activity in people with dementia: A pilot cross-sectional study.Aging medicine (Milton (N.S.W)) · 2024Article
- Prevalence, treatment, and neural correlates of apathy in different forms of dementia: a narrative review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024Review
- The neural basis of neuropsychiatric symptoms in Alzheimer's disease.Frontiers in aging neuroscience · 2024Review
- Apathy in Lewy body disease and its effects on functional impairment over time.Frontiers in neurology · 2024Article
- An Update on Apathy in Alzheimer's Disease.Geriatrics (Basel, Switzerland) · 2023Review
- A Systematic Review of Pharmacological Interventions for Apathy in Aging Neurocognitive Disorders.Brain sciences · 2023Review
- Apathy and Functional Impairment in the Course of Behavioral Variant Frontotemporal Dementia.JAMA network open · 2022Article
- Prevalent, persistent, and impairing: Longitudinal course and impact of apathy in Alzheimer's disease.Alzheimer's & dementia (Amsterdam, Netherlands) · 2021Article
- Neuropsychiatric symptom profile in neurocognitive disorders and their relationship with functional decline.Frontiers in neurologyArticle
- Speech markers of depression dimensions across cognitive status.Alzheimer's & dementia (Amsterdam, Netherlands)Article
- Apathy as a determinant of health behaviors in older adults: Implications for dementia risk reduction.Alzheimer's & dementia (Amsterdam, Netherlands)Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
introductionUnderstanding of the natural history of apathy and its impact on patient function is limited. This study examines, in a large, national sample of Alzheimer's disease (AD) patients with long follow-ups: (1) prevalence, incidence, and persistence of apathy, and (2) impact of apathy on function across dementia severity.
methodsA longitudinal study of 9823 well-characterized AD patients in the National Alzheimer's Coordinating Center Uniform Data Set.
resultsApathy was highly prevalent across disease severity with cumulative prevalence of 48%, 74%, and 82% in Clinical Dementia Rating (CDR) 0.5, 1.0, and 2.0, respectively. Persistence of apathy from clinician judgment varied from visit to visit at earlier disease stages but remained high at moderate dementia. Independent of cognition, persistent apathy was strongly associated with accelerated rate of functional decline. DISCUSSION: Findings point to important targets for the treatment and management of apathy, include functional outcomes, and study designs that account for variable persistence of the apathy syndrome.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.