Evidence map›Paper›PMID 35141325›Full record

ArticleERJ open research2022

Vitamin D supplementation in childhood asthma: a systematic review and meta-analysis of randomised controlled trials.

Jogender Kumar, Prawin Kumar, Jagdish Prasad Goyal, Chirag Thakur, Puja Choudhary, Jitendra Meena, Jaykaran Charan, Kuldeep Singh, Atul Gupta

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 8 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 8 syntheses or guidelines pooled it, 27 citations in OpenAlex.

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  6. Asthmatic patients with vitamin D deficiency: Can vitamin D supplementation make a difference.Technology and health care : official journal of the European Society for Engineering and Medicine · 2024
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  7. Vitamin D for the management of asthma.The Cochrane database of systematic reviews · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jogender KumarDept of Pediatrics, Post Graduate Institute of Medical Sciences and Research, Chandigarh, India.
Prawin KumarDept of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.ORCID https://orcid.org/0000-0002-2365-8097
Jagdish Prasad GoyalDept of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Chirag ThakurDept of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Puja ChoudharyDept of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Jitendra MeenaDept of Pediatrics, Post Graduate Institute of Medical Sciences and Research, Chandigarh, India.
Jaykaran CharanDept of Pharmacology, All India Institute of Medical Sciences, Jodhpur, India.
Kuldeep SinghDept of Pediatrics, All India Institute of Medical Sciences, Jodhpur, India.
Atul GuptaDept of Pediatric Respiratory Medicine, King's College Hospital, Institute for Women's and Children's Health, London, UK.ORCID https://orcid.org/0000-0002-1610-0335
All India Institute of Medical Sciences Jodhpur · INPost Graduate Institute of Medical Education and Research · INKing's College Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere is conflicting evidence for vitamin D supplementation in childhood asthma. We aimed to systematically synthesise the evidence on the efficacy and safety of vitamin D supplementation in childhood asthma.

methodsWe searched electronic databases (Medline, Embase and Web of Science) and a register (CENTRAL) for randomised controlled trials (RCTs) published until 30 September 2021. RCTs enrolling asthmatic children (1-18 years old) and comparing vitamin D against placebo/routine care were included if they met at least one of the endpoints of interest (asthma attacks, emergency visits or hospitalisation). We used the Risk of Bias 2 tool for risk of bias assessment. Random-effects meta-analysis with RevMan 5.3 software was performed. The Grading of Recommendations Assessment, Development and Evaluation approach was used to assess the level of certainty of the evidence.

results18 RCTs (1579 participants) were included. The pooled meta-analysis did not find a significant effect of vitamin D supplementation on asthma attacks requiring rescue systemic corticosteroids (six studies with 445 participants; risk ratio (RR) 1.13, 95% CI 0.86-1.48; I

conclusionVery low- to moderate-certainty evidence suggests that vitamin D supplementation might not have any protective effect in childhood asthma.

Identifiers

PMID35141325
PMCPMC8819253
OpenAlexW4200519069

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.