Evidence map›Paper›PMID 35141322›Full record

ArticleERJ open research2022

Association between depression and sleep apnoea: a Mendelian randomisation study.

Gui Chen, Junyang Xie, Weixing Liu, Tianhao Liang, Xiao Liao, Wenjing Liao, Lijuan Song, Xiaowen Zhang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Gui ChenState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Junyang XieState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Weixing LiuState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Tianhao LiangState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiao LiaoState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Wenjing LiaoState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Lijuan SongState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Xiaowen ZhangState Key Laboratory of Respiratory Disease, Dept of Otolaryngology - Head and Neck Surgery, First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Guangzhou Medical University · CNFirst Affiliated Hospital of Guangzhou Medical University · CNState Key Laboratory of Respiratory Disease · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStudies have reported a close relationship between depression and sleep apnoea, yet it is unknown whether these are causally related. Thus, we aimed to determine whether depression is associated with the aetiology of sleep apnoea.

methodsWe used publicly available genetic summary data from two large consortia: the Psychiatric Genomics Consortium, with data from 36 single-nucleotide polymorphisms (SNPs) closely associated with major depressive disorder (MDD), and the UK Biobank, including 456 736 patients with sleep apnoea and 766 964 controls. For Mendelian randomisation (MR) analysis, we used the inverse-variance weighted method, weighted median method, MR-Egger regression, MR pleiotropy residual sum and outlier test to retrieve summary data. Analyses were performed using the "TwoSampleMR" package in R.

resultsOut of the 36 SNPs associated with MDD, we found statistically significant evidence of a potential causal effect of MDD on the risk of sleep apnoea (OR 1.004, 95% CI 1.001-1.006; p=0.001). Similar results were obtained using the MR-Egger and weighted median methods. Additionally, we found no heterogeneity or pleiotropy.

conclusionsOur findings suggest that depression slightly increases the risk of sleep apnoea. Further investigation of the potential biological mechanisms is necessary.

Identifiers

PMID35141322
PMCPMC8819249
OpenAlexW4200543313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.