Evidence map›Paper›PMID 35141318›Full record

ArticleERJ open research2022

The impact of long-term azithromycin on antibiotic resistance in HIV-associated chronic lung disease.

Regina E Abotsi, Mark P Nicol, Grace McHugh, Victoria Simms, Andrea M Rehman, Charmaine Barthus, Lucky G Ngwira, Brenda Kwambana-Adams, Robert S Heyderman, Jon Ø Odland and 2 more

Open access · goldAbstract read
In one paragraph

Article in ERJ open research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.2field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Trial
  2. Trial
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  5. Review
  6. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 7 institutions in 8 countries.

Regina E AbotsiDepartment of Molecular and Cell Biology & Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.ORCID https://orcid.org/0000-0001-9483-3051
Mark P NicolDivision of Infection and Immunity, School of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Western Australia, Perth, Australia.
Grace McHughBiomedical Research and Training Institute, Harare, Zimbabwe.
Victoria SimmsBiomedical Research and Training Institute, Harare, Zimbabwe.ORCID https://orcid.org/0000-0002-4897-458X
Andrea M RehmanInternational Statistics and Epidemiology Group, London School of Hygiene and Tropical Medicine, London, United Kingdom.ORCID https://orcid.org/0000-0001-9967-5822
Charmaine BarthusDivision of Medical Microbiology, University of Cape Town, Cape Town, South Africa.
Lucky G NgwiraMalawi-Liverpool Wellcome Trust Clinical Research Programme, Blantyre, Malawi.
Brenda Kwambana-AdamsNIHR Global Health Research Unit on Mucosal Pathogens, Research Department of Infection, Division of Infection and Immunity, University College London, London, United Kingdom.
Robert S HeydermanNIHR Global Health Research Unit on Mucosal Pathogens, Research Department of Infection, Division of Infection and Immunity, University College London, London, United Kingdom.
Jon Ø OdlandDepartment of Community Medicine, University of Tromsø, Tromsø, Norway.
Rashida A FerrandBiomedical Research and Training Institute, Harare, Zimbabwe.
Felix S DubeDepartment of Molecular and Cell Biology & Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
London School of Hygiene & Tropical Medicine · GBUniversity of Cape Town · ZAUniversity College London · GBBiomedical Research and Training Institute · ZWNational Research University Higher School of Economics · RUThe University of Western Australia · AUUniversity of Liverpool · GB

Funding

Medical Research Council MR/R010161/1Wellcome Trust 206316/Z/17/Z
6 · The paper itself

Abstract

Selection for resistance to azithromycin (AZM) and other antibiotics such as tetracyclines and lincosamides remains a concern with long-term AZM use for treatment of chronic lung diseases (CLD). We investigated the impact of 48 weeks of AZM on the carriage and antibiotic resistance of common respiratory bacteria among children with HIV-associated CLD. Nasopharyngeal (NP) swabs and sputa were collected at baseline, 48 and 72 weeks from participants with HIV-associated CLD randomised to receive weekly AZM or placebo for 48 weeks and followed post-intervention until 72 weeks. The primary outcomes were prevalence and antibiotic resistance of

Identifiers

PMID35141318
PMCPMC8819245
OpenAlexW3214129022

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.