Evidence map›Paper›PMID 35141201›Full record

ArticleFrontiers in chemistry2022

IR780 Based Sonotherapeutic Nanoparticles to Combat Multidrug-Resistant Bacterial Infections.

Biying Huang, Long Wang, Kui Tang, Sijie Chen, Yan Xu, Haiqin Liao, Chengcheng Niu

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in chemistry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
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  5. AnRecent advances in anti-infective drug discovery · 2025
    Article
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  7. HJournal of nanobiotechnology · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Biying HuangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Long WangDepartment of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.
Kui TangDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Sijie ChenDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Yan XuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Haiqin LiaoDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Chengcheng NiuDepartment of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, China.
Central South University · CNSecond Xiangya Hospital of Central South University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Multidrug-resistant (MDR) bacterial strains have emerged and weakened the therapeutic effects of antibacterial drugs. Sonodynamic therapy (SDT) takes advantage of noninvasiveness and deep tissue-penetrating features and has been rejuvenated to combat MDR bacteria and their biofilm-associated infections. To improve the efficacy of antibacterial SDT, we first developed IR780-based PLGA nanoparticles as sonosensitizers for high-frequency ultrasound (US)-monitored antibacterial SDT of MRSA myositis by therapeutic low-frequency US. In this study, the developed shell-core-structured IR780@PLGA nanoparticles were designed with a polymer shell PLGA with the sonosensitizer IR780 loaded on. High-frequency diagnostic US was introduced to monitor the sonotherapeutic progression of bacterial myositis by therapeutic low-frequency US. Importantly, the

Indexed as

antibacterial therapyIR780multidrug-resistant bacterial infectionsreactive oxygen speciessonodynamic therapy

Identifiers

PMID35141201
PMCPMC8818736
OpenAlexW4206959061

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.