Evidence map›Paper›PMID 35141177›Full record

ArticleFrontiers in pediatrics2021

Association Between NT-proBNP and Prolonged Length of Stay in Hospital Among Preterm Infants Born at 28-31 Weeks' Gestation.

Jian Ge, Chenghan Luo, Mengyuan Lei, Zanyang Shi, Xinru Cheng, Min Zhao, Yanting Zhao, Min Song, Wenqian Ding, Mengmeng Wang and 8 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
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  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Jian GeThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Chenghan LuoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mengyuan LeiThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Zanyang ShiThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Xinru ChengThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Min ZhaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Yanting ZhaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Min SongThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenqian DingThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Mengmeng WangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Wenjun CaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Fengxia MaoThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Suge HanThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qianya XuThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Junbo WangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Haoqi QinThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Li WangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Qian ZhangThe First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
First Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIn the early life of preterm infants, the relationship between heart function and length of hospitalization is unclear. This study aims to examine the association between serum NT-proBNP level on the 7th day (NT-proBNP7) after birth and length of hospitalization among preterm infants.

methodsA retrospective cohort study was conducted. Patients included 709 preterm infants born at 28-31 weeks' gestational age (GA) admitted to the NICU of the First Affiliated Hospital of Zhengzhou University between December 20, 2016, to April 31, 2021. Main outcome: Late discharge (postmenstrual age at discharge was in the fourth quartile (highest) among infants born at the same GA). Exposure factor: NT-proBNP7.

resultsWe observed increased prevalence ratios for late discharge among the tertile of logarithm of NT-proBNP7 level (LnNT-proBNP7) which was positive. Compared with the lowest tertile, infants in the highest tertile of LnNT-proBNP7 had an 8.4-fold increased probability of late discharge, and the results were consistent for the subgroups. Next, a non-linear (S-shaped) relationship between LnNT-proBNP7 and late discharge was observed, whose turning points were 7.5 and 9. The effect sizes and the confidence intervals on the left of the first turning point, between two turning points and on the right of the second turning point, were 0.6 (95% CI, 0.2-1.6), 5.0 (95% CI, 2.4-10.6), and 1.1 (95% CI, 0.2-6.1), respectively. In addition, the prevalence of BPD, NEC, nosocomial infection, or any of them was highest in the group of LnNT-proBNP7 ≥ 9, lowest in the group of LnNT-proBNP7 < 7.5.

conclusionHigher NT-proBNP7 levels were associated with longer hospitalization. The relationship between LnNT-proBNP7 and late discharge was S-shaped. LnNT-proBNP7 was positively related with late discharge when LnNT-proBNP7 was between 7.5 and 9.

Indexed as

cardiac functionduration of hospitalizationlength of stayN-terminal pro-brain natriuretic peptidepreterm infants

Identifiers

PMID35141177
PMCPMC8819076
OpenAlexW4207018185

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.