Evidence map›Paper›PMID 35141173›Full record

ArticleFrontiers in cellular and infection microbiology2021

Probing Immune-Mediated Clearance of Acute Middle Ear Infection in Mice.

Kalyan K Dewan, Colleen Sedney, Amanda D Caulfield, Yang Su, Longhuan Ma, Uriel Blas-Machado, Eric T Harvill

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
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  3. Complete genome sequence ofMicrobiology resource announcements · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Kalyan K DewanDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Colleen SedneyDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Amanda D CaulfieldDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Yang SuDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Longhuan MaDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Uriel Blas-MachadoDepartment of Pathology, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
Eric T HarvillDepartment of Infectious Diseases, College of Veterinary Medicine, University of Georgia, Athens, GA, United States.
University of Georgia · US

Funding

Evolution of the Bordetellae from Commensals to PathogensR01GM083113 · NIGMS · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2008 to 2011
$2.1M
Comparative Immunobiology of the bordetellaeR01AI053075 · NIAID · PENNSYLVANIA STATE UNIVERSITY-UNIV PARK · PI HARVILL, ERIC T. · 2003 to 2007
$1.4M
The Microbiota Pathogen CompetitionR01GM113681 · NIGMS · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2018
$1.3M
Are acellular vaccines driving the rise of pertactin-deficient Bordetella pertussisR21AI156293 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
Protection against Bordetella pertussis transmission conferred by established and novel vaccinesR21AI159347 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2021 to 2022
$415k
Bacterial factors and host response in chronic otitis mediaR21DC018496 · NIDCD · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2020 to 2021
$415k
An optimized mouse model of Bordetella pertussis infectionR21AI142678 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2019 to 2020
$414k
In vivo vaccine-driven evolution in Bordetella pertussisR21AI116186 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2015 to 2016
$411k
Bordetella sp. Versus MicrobiotaR56AI107016 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T · 2014 to 2014
$377k
Vaccine targeting catarrhal stage of pertussis diseaseR56AI149787 · NIAID · UNIVERSITY OF GEORGIA · PI HARVILL, ERIC T · 2020 to 2020
$369k
EMERGENCE OF HUMAN PATHOGENS IN THE GENUS BORDETELLAR56AI065507 · NIAID · PENNSYLVANIA STATE UNIVERSITY, THE · PI HARVILL, ERIC T. · 2007 to 2007
$363k
NIAID NIH HHS R01 AI053075NIAID NIH HHS R21 AI116186NIAID NIH HHS R21 AI142678NIAID NIH HHS R21 AI156293NIAID NIH HHS R21 AI159347NIAID NIH HHS R56 AI065507NIAID NIH HHS R56 AI107016NIAID NIH HHS R56 AI149787NIDCD NIH HHS R21 DC018496NIGMS NIH HHS R01 GM083113NIGMS NIH HHS R01 GM113681
6 · The paper itself

Abstract

Acute otitis media (AOM) is commonly caused by bacterial pathobionts of the nasopharynx that ascend the Eustachian tube to cause disease in the middle ears. To model and study the various complexities of AOM, common human otopathogens are injected directly into the middle ear bullae of rodents or are delivered with viral co-infections which contribute to the access to the middle ears in complex and partially understood ways. Here, we present the novel observation that

Indexed as

Bordetella bronchisepticaEustachian TubeOtitis MediaAnimalsEar, MiddleMiceNasopharynxadaptive immunityBordetella bronchisepticanatural infectionotitis mediaprotective immunity

Identifiers

PMID35141173
PMCPMC8818953
OpenAlexW4207082296

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.