Evidence map›Paper›PMID 35141168›Full record

ArticleFrontiers in cellular and infection microbiology2021

Antimicrobial Activity of a Repurposed Harmine-Derived Compound on Carbapenem-Resistant

Anke Breine, Mégane Van Gysel, Mathias Elsocht, Clémence Whiteway, Chantal Philippe, Théo Quinet, Adam Valcek, Johan Wouters, Steven Ballet, Charles Van der Henst

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Journal of medical microbiology · 2026
    Article
  3. mBio · 2025
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Anke BreineMicrobial Resistance and Drug Discovery, Vlaams Instituut voor Biotechnologie-Vrije Universiteit Brussel (VIB-VUB) Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Flanders Institute for Biotechnology, Brussels, Belgium.
Mégane Van GyselNamur Medicine and Drug Innovation Center (NAMEDIC), University of Namur (UNamur), Namur, Belgium.
Mathias ElsochtResearch Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Clémence WhitewayMicrobial Resistance and Drug Discovery, Vlaams Instituut voor Biotechnologie-Vrije Universiteit Brussel (VIB-VUB) Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Flanders Institute for Biotechnology, Brussels, Belgium.
Chantal PhilippeResearch Unit in the Biology of Microorganisms (URBM), NARILIS, University of Namur (UNamur), Namur, Belgium.
Théo QuinetLaboratory of Evolutionary Genetics and Ecology, URBE, University of Namur (UNamur), Namur, Belgium.
Adam ValcekMicrobial Resistance and Drug Discovery, Vlaams Instituut voor Biotechnologie-Vrije Universiteit Brussel (VIB-VUB) Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Flanders Institute for Biotechnology, Brussels, Belgium.
Johan WoutersNamur Medicine and Drug Innovation Center (NAMEDIC), University of Namur (UNamur), Namur, Belgium.
Steven BalletResearch Group of Organic Chemistry, Departments of Chemistry and Bioengineering Sciences, Vrije Universiteit Brussel, Brussels, Belgium.
Charles Van der HenstMicrobial Resistance and Drug Discovery, Vlaams Instituut voor Biotechnologie-Vrije Universiteit Brussel (VIB-VUB) Center for Structural Biology, Vlaams Instituut voor Biotechnologie (VIB), Flanders Institute for Biotechnology, Brussels, Belgium.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesThe spread of antibiotic resistant bacteria is an important threat for human health.

methodsA repurposing drug screen was undertaken to identify

resultsThe repurposing screen led to the identification of a harmine-derived compound, called HDC1, which proves to have bactericidal activity on the multidrug-resistant AB5075-VUB reference strain with an IC

conclusionsWe identified a compound with inhibitory activity on all tested strains, including carbapenem-resistant clinical

Indexed as

Acinetobacter baumanniiAcinetobacter InfectionsAnti-Bacterial AgentsCarbapenemsHarmineHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsCarbapenemsHarmineAcinetobacter baumanniicarbapenem-resistantdrug screeningGram-negativepathogenic bacteriarepurposed compound

Identifiers

PMID35141168
PMCPMC8819726

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.