Evidence map›Paper›PMID 35141021›Full record

ArticleAmerican journal of cancer research2022

STAMP2 suppresses autophagy in prostate cancer cells by modulating the integrated stress response pathway.

Jørgen Sikkeland, Matthew Yoke Wui Ng, Hatice Zeynep Nenseth, Bilal Unal, Su Qu, Yang Jin, Anne Simonsen, Fahri Saatcioglu

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in American journal of cancer research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jørgen SikkelandDepartment of Biosciences, University of Oslo Postboks 1066 Blindern, Oslo 0316, Norway.
Matthew Yoke Wui NgDepartment of Biosciences, University of Oslo Postboks 1066 Blindern, Oslo 0316, Norway.
Hatice Zeynep NensethDepartment of Biosciences, University of Oslo Postboks 1066 Blindern, Oslo 0316, Norway.
Bilal UnalInstitute for Cancer Genetics and Informatics, Oslo University Hospital Oslo 0310, Norway.
Su QuDepartment of Biosciences, University of Oslo Postboks 1066 Blindern, Oslo 0316, Norway.
Yang JinDepartment of Biosciences, University of Oslo Postboks 1066 Blindern, Oslo 0316, Norway.
Anne SimonsenDepartment of Molecular Medicine, Institute of Basic Medical Sciences and Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo Oslo 0313, Norway.
Fahri SaatciogluDepartment of Biosciences, University of Oslo Postboks 1066 Blindern, Oslo 0316, Norway.
Oslo University Hospital · NOUniversity of Oslo · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Six Transmembrane Protein of Prostate 2 (STAMP2) is critical for prostate cancer (PCa) growth. We previously showed that STAMP2 regulates the expression of stress induced transcription factor ATF4, which is implicated in starvation-induced autophagy. We therefore investigated whether STAMP2 is involved in the regulation of autophagy in PCa cells. Here we show that STAMP2 suppresses autophagy in PCa cells through modulation of the integrated stress response axis. We also find that STAMP2 regulates mitochondrial respiration. These findings suggest that STAMP2 has significant metabolic effects through mitochondrial function and autophagy, both of which support PCa growth.

Indexed as

ATF4autophagyeIF2αintegrated stress responsemitochondriaProstate cancerSTAMP2

Identifiers

PMID35141021
PMCPMC8822275
OpenAlexW4211266932

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.