Evidence map›Paper›PMID 35140842›Full record

ArticleMalawi medical journal : the journal of Medical Association of Malawi2020

Non-communicable respiratory disease in Malawi: a systematic review and meta-analysis.

Rebecca Nightingale, Hannah Jary, Jamilah Meghji, Sarah Rylance, Jones Masiye, Hastings Chiumia, Jamie Rylance, Kevin Mortimer, Maia Lesosky

Open access · diamondAbstract read
In one paragraph

Article in Malawi medical journal : the journal of Medical Association of Malawi, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 2 countries.

Rebecca NightingaleLiverpool School of Tropical Medicine, Liverpool, UK.
Hannah JaryPopulation Health Science Institute, Newcastle University, Newcastle, UK.
Jamilah MeghjiLiverpool School of Tropical Medicine, Liverpool, UK.
Sarah RylanceLiverpool School of Tropical Medicine, Liverpool, UK.
Jones MasiyeMinistry of Health, Government of Malawi, Malawi.
Hastings ChiumiaMinistry of Health, Government of Malawi, Malawi.
Jamie RylanceLiverpool School of Tropical Medicine, Liverpool, UK.
Kevin MortimerLiverpool School of Tropical Medicine, Liverpool, UK.
Maia LesoskyDivision of Epidemiology & Biostatistics, School of Public Health & Family Medicine, University of Cape Town, South Africa.
University of Liverpool · GB

Funding

Medical Research Council MR/P022006/1Medical Research Council MR/S02042X/1
6 · The paper itself

Abstract

backgroundNon-communicable respiratory diseases are important contributors to morbidity and mortality in sub-Saharan African countries such as Malawi.

aimTo conduct a systematic review of the available literature relating to chronic respiratory disease in Malawi.

methodsWe conducted a systematic protocol-driven literature search of key scientific databases including Scopus and Medline. Papers were independently assessed for eligibility by two authors and included if they reported objective measures (including self-reported standard symptoms) of chronic respiratory disease and were conducted in Malawi. A meta-analysis of available estimates was then conducted. We re-analysed data from three of these studies in a secondary data analysis to allow for between-study comparisons.

resultsOur search identified 393 papers of which 17 (5 involving children and 12 involving adults) met the inclusion criteria. Wheeze was the symptom most frequently reported in children in the community (12.1%), hospital (11.2%) and HIV clinic (8.1%) settings. Cough was the symptom most frequently reported by adults in the community (3-18%). Spirometric abnormalities varied substantially between studies. For example, in adults, airflow obstruction varied between 2.3% and 20% and low forced vital capacity (FVC) varied between 2.7% and 52.8%.

conclusionWe identified a high burden of chronic respiratory symptoms and abnormal spirometry (particularly low FVC) within paediatric and adult populations in Malawi. The estimates for country-wide burden related to this disease were limited by the heterogeneity of the methods used to assess symptoms and spirometry. There is an urgent need to develop a better understanding of the determinants and natural history of non-communicable respiratory disease across the life-course in Malawi.

Indexed as

asthmachronic lung diseaseCOPDcoughMalawinon-communicable disease

Identifiers

PMID35140842
PMCPMC8788589
OpenAlexW3040914120

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.