Evidence map›Paper›PMID 35140788›Full record

ArticleJournal of oncology2022

A TRP Family Based Signature for Prognosis Prediction in Head and Neck Squamous Cell Carcinoma.

Fangfang Pan, Kai Wang, Mengmeng Zheng, Yuan Ren, Wenjuan Hao, Jiangyu Yan

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Article in Journal of oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Fangfang PanDepartment of Otorhinolaryngology Head and Neck Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.ORCID https://orcid.org/0000-0001-9573-4784
Kai WangDepartment of Otorhinolaryngology Head and Neck Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.ORCID https://orcid.org/0000-0002-1282-6833
Mengmeng ZhengDepartment of Otorhinolaryngology Head and Neck Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.ORCID https://orcid.org/0000-0002-4824-9476
Yuan RenDepartment of Otorhinolaryngology Head and Neck Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.ORCID https://orcid.org/0000-0002-3991-5342
Wenjuan HaoDepartment of Otorhinolaryngology Head and Neck Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.ORCID https://orcid.org/0000-0003-4289-3401
Jiangyu YanDepartment of Otorhinolaryngology Head and Neck Surgery, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo 315010, China.ORCID https://orcid.org/0000-0001-9638-8756

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeHead and neck squamous cell carcinoma (HNSCC) is a classical type of head and neck cancers, with heterogeneous clinical outcome. This project is set out to create a robust risk signature based on TRP family genes (TFGs) for prognosis evaluation in HNSCC.

methodsBased on the HNSCC sample data from the TCGA website, we integrated expression profile of TFGs for 490 HNSCC cases. We explore the interactions among TFGs using STRING tool. The TFGs-based signature (TFBS) was created by Cox relative analyses. In addition, we conducted GSEA to identify the underlying signaling pathways of the specific TFGs in HNSCC. The immune landscape of HNSCC patients was analyzed by CIBERSORT and ssGSEA algorithms.

resultsA total of 6 TFGs (TRPC1, TRPC3, TRPC6, TRPV2, TRPV4, and TRPM8) closely associated with prognosis of HNSCC cases were screened to create TFBS. TFBS predicted that the TFBS-high group presented dismal patient outcome. Cox regression revealed the favorable independent value of TFBS. ROC analysis showed the robust power of TFBS for prognosis forecasting. GSEA determined several crucial pathways related with HNSCC, which are the p53 pathway, TNF-alpha signaling via NFKB, and hypoxia. Moreover, immune-related analysis showed that patients in the TFBS-high group were more likely in immunosuppressive status.

conclusionOur proposed TFBS could serve as a favorable indicator to forecast the survival outcome of HNSCC cases and offer prominent therapy guidance.

Identifiers

PMID35140788
PMCPMC8820906

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