Evidence map›Paper›PMID 35140781›Full record

Trial reportNeural plasticity2022

Temporal Interference (TI) Stimulation Boosts Functional Connectivity in Human Motor Cortex: A Comparison Study with Transcranial Direct Current Stimulation (tDCS).

Zhiqiang Zhu, Yiwu Xiong, Yun Chen, Yong Jiang, Zhenyu Qian, Jianqiang Lu, Yu Liu, Jie Zhuang

Open access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Neural plasticity, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
31citing papers in PubMed, 1 pooled it
4.9field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

31 citing papers in PubMed, 1 synthesis or guideline pooled it, 59 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Zhiqiang ZhuThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.
Yiwu XiongThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.
Yun ChenThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.
Yong JiangThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.
Zhenyu QianThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.
Jianqiang LuThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.
Yu LiuThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.ORCID 0000-0001-6253-6132
Jie ZhuangThe Research Group of "The Effects of Non-Invasive Deep Brain Stimulation on Improving Human Performance and Its Mechanisms", Shanghai University of Sport, Shanghai 200438, China.ORCID 0000-0002-3316-5536
Shanghai University of Sport · CNShenzhen University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Temporal interference (TI) could stimulate deep motor cortex and induce movement without affecting the overlying cortex in previous mouse studies. However, there is still lack of evidence on potential TI effects in human studies. To fill this gap, we collected resting-state functional magnetic resonance imaging data on 40 healthy young participants both before and during TI stimulation on the left primary motor cortex (M1). We also chose a widely used simulation approach (tDCS) as a baseline condition. In the stimulation session, participants were randomly allocated to 2 mA TI or tDCS for 20 minutes. We used a seed-based whole brain correlation analysis method to quantify the strength of functional connectivity among different brain regions. Our results showed that both TI and tDCS significantly boosted functional connection strength between M1 and secondary motor cortex (premotor cortex and supplementary motor cortex). This is the first time to demonstrate substantial stimulation effect of TI in the human brain.

Indexed as

Motor CortexTranscranial Direct Current StimulationAnimalsBrainEvoked Potentials, MotorHumansMagnetic Resonance ImagingMiceMovement

Identifiers

PMID35140781
PMCPMC8820942
OpenAlexW4211097817

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.