Evidence map›Paper›PMID 35140703›Full record

SynthesisFrontiers in immunology2021

Causal Relationship Between Gut Microbiota and Autoimmune Diseases: A Two-Sample Mendelian Randomization Study.

Qian Xu, Jing-Jing Ni, Bai-Xue Han, Shan-Shan Yan, Xin-Tong Wei, Gui-Juan Feng, Hong Zhang, Lei Zhang, Bin Li, Yu-Fang Pei

Registry-linked trialOpen access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06249074 (The Impact of Gluten-free Diet on the Thyroid Function, Quality of Life and Gut Microbiome Composition in Women With Autoimmune Thyroiditis), which is not on this map. Cited by 186 papers, 10 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
186citing papers in PubMed, 10 pooled it
26.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06249074 nacompletednot on this map

The Impact of Gluten-free Diet on the Thyroid Function, Quality of Life and Gut Microbiome Composition in Women With Autoimmune Thyroiditis

TypeinterventionalSponsorMedical University of GdanskRan2020 to 2021Enrolled31ConditionsAutoimmune ThyroiditisArmsGluten-free diet, Gluten capsules supplementation, Placebo capsules supplementation
3 · Its place in the literature

Who cites it

186 citing papers in PubMed, 10 syntheses or guidelines pooled it, 292 citations in OpenAlex.

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126 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Qian XuDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Jing-Jing NiDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Bai-Xue HanDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Shan-Shan YanDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Xin-Tong WeiDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Gui-Juan FengDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Hong ZhangDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Lei ZhangJiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou, China.
Bin LiDepartment of General Surgery, Suzhou Ninth Hospital Affiliated to Soochow University, Affiliated Wujiang Hospital of Nantong University, Suzhou, China.
Yu-Fang PeiDepartment of Epidemiology and Biostatistics, School of Public Health, Medical College of Soochow University, Suzhou, China.
Soochow University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Growing evidence has shown that alterations in gut microbiota composition are associated with multiple autoimmune diseases (ADs). However, it is unclear whether these associations reflect a causal relationship. Objective: To reveal the causal association between gut microbiota and AD, we conducted a two-sample Mendelian randomization (MR) analysis. Materials and Methods: We assessed genome-wide association study (GWAS) summary statistics for gut microbiota and six common ADs, namely, systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, type 1 diabetes (T1D), and celiac disease (CeD), from published GWASs. Two-sample MR analyses were first performed to identify causal bacterial taxa for ADs in discovery samples. Significant bacterial taxa were further replicated in independent replication outcome samples. A series of sensitivity analyses was performed to validate the robustness of the results. Finally, a reverse MR analysis was performed to evaluate the possibility of reverse causation. Results: Combining the results from the discovery and replication stages, we identified one causal bacterial genus, Conclusion: This study implied a causal relationship between the

Indexed as

AdultAgedArthritis, RheumatoidAutoimmune DiseasesCausalityCeliac DiseaseDiabetes Mellitus, Type 1Gastrointestinal MicrobiomeGenome-Wide Association StudyHumansInflammatory Bowel DiseasesLupus Erythematosus, SystemicMendelian Randomization AnalysisMiddle AgedMultiple SclerosisPolymorphism, Single Nucleotideautoimmune disease (AD)celiac diseasegut microbiotaMendelian randomizationtype 1 diabetes

Identifiers

PMID35140703
PMCPMC8819003
OpenAlexW4206900879

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.