Evidence map›Paper›PMID 35140702›Full record

Observational studyFrontiers in immunology2021

Is There a Crucial Link Between Vitamin D Status and Inflammatory Response in Patients With COVID-19?

Federica Saponaro, Maria Franzini, Chukwuma Okoye, Rachele Antognoli, Beatrice Campi, Marco Scalese, Tommaso Neri, Laura Carrozzi, Fabio Monzani, Riccardo Zucchi and 3 more

Open access · goldAbstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  6. Review
  7. Review
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  11. Vitamin D as a predictor of negative outcomes in hospitalized COVID-19 patients: An observational study.Canadian journal of respiratory therapy : CJRT = Revue canadienne de la therapie respiratoire : RCTR · 2023
    Article
  12. Article
  13. Review
  14. The Role of Vitamin D in Supporting Health in the COVID-19 Era.International journal of molecular sciences · 2022
    Review
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  16. Article
  17. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Federica SaponaroDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Maria FranziniDepartment of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.
Chukwuma OkoyeDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Rachele AntognoliDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Beatrice CampiDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Marco ScaleseInstitute of Clinical Physiology, National Council of Research, Pisa, Italy.
Tommaso NeriDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Laura CarrozziDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Fabio MonzaniDepartment of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Riccardo ZucchiDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Alessandro CeliDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
Aldo PaolicchiDepartment of Translational Research and New Technologies in Medicine, University of Pisa, Pisa, Italy.
Alessandro SabaDepartment of Surgical, Medical, and Molecular Pathology and Critical Care Medicine, University of Pisa, Pisa, Italy.
University of Pisa · ITNational Research Council · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Hypovitaminosis D has been suggested to play a possible role in coronavirus disease 2019 (COVID-19) infection. Methods: The aim of this study is to analyze the relationship between vitamin D status and a biochemical panel of inflammatory markers in a cohort of patients with COVID-19. A secondary endpoint was to evaluate the correlation between 25OHD levels and the severity of the disease. Ninety-three consecutive patients with COVID-19-related pneumonia were evaluated from March to May 2020 in two hospital units in Pisa, in whom biochemical inflammatory markers, 25OHD levels, P/F ratio at nadir during hospitalization, and complete clinical data were available. Results: Sixty-five percent of patients presented hypovitaminosis D (25OHD ≤ 20 ng/ml) and showed significantly higher IL-6 [20.8 (10.9-45.6) vs. 12.9 (8.7-21.1) pg/ml, Conclusions: The relationship between 25OHD levels and inflammatory markers suggests that vitamin D status needs to be taken into account in the management of these patients. If vitamin D is a marker of poor prognosis or a possible risk factor with beneficial effects from supplementation, this still needs to be elucidated.

Indexed as

COVID-19Vitamin D DeficiencyAgedAged, 80 and overCytokinesDisease-Free SurvivalFemaleHumansInflammationMaleMiddle AgedRetrospective StudiesSARS-CoV-2Survival RateVitamin D25-hydroxyvitamin DCytokinesVitamin DCOVID-19cytokine stormhypovitaminosis DSARS-CoV-2vitamin D

Identifiers

PMID35140702
PMCPMC8818986
OpenAlexW4207059570

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.