Evidence map›Paper›PMID 35140683›Full record

ArticleFrontiers in endocrinology2021

ANGPTL4 Expression in Ovarian Granulosa Cells Is Associated With Polycystic Ovary Syndrome.

Qi Jiang, Ye Pan, Ping Li, Yanjun Zheng, Yuehong Bian, Wenqi Wang, Guihua Wu, Tian Song, Yuhua Shi

Abstract read
In one paragraph

Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Evaluation of angiopoietin-like protein 4 levels in patients with endometriosis.Journal of the Turkish German Gynecological Association · 2026
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  6. The combination of circulating levels of ANGPTL, omentin-1, leptin and cytokines is associated with polycystic ovary syndrome in different BMI groups.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2025
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  7. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Qi JiangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ye PanCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Ping LiWomen and Children's Hospital, School of Medicine, Xiamen University, Xiamen, China.
Yanjun ZhengCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yuehong BianCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Wenqi WangCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Guihua WuShandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China.
Tian SongCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.
Yuhua ShiCenter for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Jinan, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: This study aims to characterize the expression of ANGPTL4 in ovarian granulosa cells (GCs) and its association with polycystic ovary syndrome (PCOS). Methods: This study included 104 PCOS patients and 112 women in control group undergoing Results: The RT-qPCR results showed that ANGPTL4 expression in the control group was significantly lower than that in the PCOS group ( Conclusions: Our study revealed higher ANGPTL4 expression in ovarian GCs with PCOS. Its association with glucose and lipid metabolism showed that ANGPTL4 might play an important role in PCOS metabolism and pathogenesis.

Indexed as

AdultAngiopoietin-Like Protein 4Anti-Mullerian HormoneApolipoprotein A-IApolipoproteins BCase-Control StudiesEmbryo TransferFemaleFertilization in VitroGranulosa CellsHumansInsulin ResistanceLipoproteins, HDLLipoproteins, LDLPolycystic Ovary SyndromeReal-Time Polymerase Chain ReactionAngiopoietin-Like Protein 4ANGPTL4 protein, humanAnti-Mullerian HormoneApolipoprotein A-IApolipoproteins BLipoproteins, HDLLipoproteins, LDLRNA, MessengerTriglyceridesangiopoietin-like protein 4glycolipid metabolismmRNAovarian granulosa cellpolycystic ovary syndrome

Identifiers

PMID35140683
PMCPMC8820586

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.