ArticleFrontiers in endocrinology2021
The Effects of Endometrial Thickness on Pregnancy Outcomes of Fresh IVF/ICSI Embryo Transfer Cycles: An Analysis of Over 40,000 Cycles Among Five Reproductive Centers in China.
Article in Frontiers in endocrinology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Impact of endometrial thickness on reproductive outcome in fresh and frozen-thawed embryo transfer: systematic review and meta-analysis.Ultrasound in obstetrics & gynecology : the official journal of the International Society of Ultrasound in Obstetrics and Gynecology · 2025Pooled it
- Vasodilators for women undergoing fertility treatment.The Cochrane database of systematic reviews · 2025Pooled it
- Correlation of low birth weight with infertility and ART treatment: single-center cohort analysis of 7697 singleton live births.BMC pregnancy and childbirth · 2026Article
- Association between endometrial thickness and cumulative live birth rate in one oocyte-retrieval cycle: a retrospective cohort study including 26,127 patients.BMC pregnancy and childbirth · 2026Article
- Impact of intrauterine infusion of human umbilical cord blood mononuclear cells on reproductive outcomes in patients with thin endometrium undergoing frozen embryo transfer.Frontiers in cell and developmental biology · 2026Article
- Polycystic ovary syndrome and miscarriage risk: dual evidence from cohort study and Mendelian randomization.Frontiers in endocrinology · 2026Article
- Development and validation of a nomogram integrating endometrial ultrasound parameters to predict clinical pregnancy in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2026Article
- Association of Ambient Air Pollution and Pregnancy Outcomes Among Women with Assisted Reproductive Technology in Qingdao, China: A Retrospective Cohort Study.Risk management and healthcare policy · 2026Article
- The impact of the interaction between ovarian markers and the endometrium on the outcomes of assisted reproduction.Frontiers in cell and developmental biology · 2026Article
- Linear association between endometrial thickness and live birth in single blastocyst transfers: A dual-center retrospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2025Article
- Predictive model for live birth outcomes in single euploid frozen embryo transfers: a comparative analysis of logistic regression and machine learning approaches.Journal of assisted reproduction and genetics · 2025Article
- Plasminogen activator inhibitor 1 is a novel predictor in human serum/follicular fluid for diminished ovarian reserve.BMC women's health · 2025Article
- The influence of endometrial thickness on clinical pregnancy outcomes in early-follicular long-acting and midluteal short-acting GnRH agonist long protocols: a large retrospective study.Frontiers in endocrinology · 2025Article
- The effect of atosiban on pregnancy outcomes in different FET cycles: a single-center matched retrospective cohort study.Frontiers in endocrinology · 2025Article
- Study on the relationship between endometrial thickness on the hCG day in the progestin-primed ovarian stimulation protocol and pregnancy outcomes in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2025Article
- Interplay of endocrine and psychological factors in IVF/ICSI outcomes: a prospective cohort analysis.Frontiers in endocrinology · 2025Article
- Evaluation of endometrial receptivity in women with unexplained infertility by shear wave elastography.Insights into imaging · 2024Article
- Platelet-rich plasma infusion as an adjunct treatment for persistent thin lining in frozen embryo transfer cycles: first US experience report.Journal of assisted reproduction and genetics · 2024Article
- A predictive model for clinical pregnancy following single Day-6 blastocyst transfer in frozen-thawed embryo transfer cycles.Frontiers in endocrinology · 2024Article
- A critical appraisal of studies on endometrial thickness and embryo transfer outcome.Reproductive biomedicine online · 2023Review
Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To investigate the effects of endometrial thickness (EMT) on pregnancy outcomes on hCG trigger day in fresh Methods: A total of 42,132 fresh cycles between 1 January 2013 and 31 December 2019 were included in this retrospective cohort study. Data were collected from five reproductive centers of large academic or university hospitals in China. All patients were divided into different groups according to their endometrial thickness on hCG trigger day. Multivariate regression analysis, curve fitting and threshold effect analysis were performed. Results: After adjusting for age, body mass index, infertility type, number of embryos transferred, number of retrieved oocytes and COS (controlled ovarian stimulation) protocols, significant associations were found between endometrial thickness and clinical pregnancy rate (adjusted odds ratio [aOR]: 1.05; 95% confidence interval [CI]: 1.06-1.08, P < 0.0001), live birth rate (aOR: 1.04; 95% CI: 1.03-1.05, P < 0.0001) as well as miscarriage rate(aOR: 0.96; 95% CI: 0.94 - 0.98, P < 0.0001). When the endometrial thickness was less than 12mm, the clinical pregnancy rate and live birth rate were increased significantly by 10% and 9%(OR:1.10; 95%CI: 1.08-1.12, OR:1.09; 95%CI: 1.07-1.11), respectively, along with the increase of each millimeter increment of endometrial thickness. However, when the EMT ranged from 12-15 mm, were stable at the ideal level, that were not significantly associated with EMT growth. Additionally, clinical pregnancy rate and live birth rate were slightly reduced by 6% and 4% when EMT was ≥15mm. Meanwhile, the miscarriage rate was significantly declined by 8% (OR:0.92; 95%CI: 0.90-0.95)with each millimeter increment of EMT. And when EMT was thicker than 12mm, the miscarriage rate didn't change any more significantly. Conclusions: Endometrial thickness exhibits a curvilinear relationship with pregnancy outcomes in fresh embryo transfer cycles. Clinical pregnancy rate, live birth rate and miscarriage rate may achieve their optimal level when EMT ≥ 12 mm, but some adverse pregnancy outcomes would be observed when EMT ≥15 mm especially for clinical pregnancy.
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