SynthesisFrontiers in physiology2021
Assisted Oocyte Activation With Calcium Ionophore Improves Pregnancy Outcomes and Offspring Safety in Infertile Patients: A Systematic Review and Meta-Analysis.
Synthesis in Frontiers in physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 33 citations in OpenAlex.
- Insights into The Outcomes of Artificial Oocyte Activation: A Retrospecive Analysis of 1,300 Couples Undergoing Intracytoplasmic Sperm Injection.International journal of fertility & sterility · 2026Article
- Assisted oocyte activation re-envisioned: a more physiological approach.Journal of assisted reproduction and genetics · 2026Article
- Round Spermatid Injection (ROSI) as a Last Resort in High-Risk Azoospermia: Chain of Outcome Metrics and Real-World Safety Signals.Journal of clinical medicine · 2026Article
- The efficacy of ionomycin - induced artificial oocyte activation in preventing fertilization failure in an ICSI cycle: an eight - year retrospective study.Journal of ovarian research · 2025Article
- Article
- Artificial oocyte activation technology as adjuvant therapy for primary ciliary dyskinesia: a report of eight cases and literature review.Journal of assisted reproduction and genetics · 2025Review
- Add-On Technologies That Aim to Improve Oocyte Quality and Embryo Implantation Potential.Medicina (Kaunas, Lithuania) · 2025Review
- Development of Recombinant PLC-Zeta Protein as a Therapeutic Intervention for the Clinical Treatment of Oocyte Activation Failure.Biomedicines · 2024Article
- Aggressive sperm immobilization improves reproductive outcomes in patients with suboptimal semen parameters and previous ICSI fertilization failure.Scientific reports · 2024Article
- Good practice recommendations on add-ons in reproductive medicine†.Human reproduction (Oxford, England) · 2023Article
- Significant differences in efficiency between two commonly used ionophore solutions for assisted oocyte activation (AOA): a prospective comparison of ionomycin and A23187.Journal of assisted reproduction and genetics · 2023Article
- Live birth rate following a failed first in vitro fertilization cycle with no embryos for transfer.Scientific reports · 2023Article
- Artificial oocyte activation using CaFrontiers in endocrinology · 2023Article
- IQCN disruption causes fertilization failure and male infertility due to manchette assembly defect.EMBO molecular medicine · 2022Article
- Artificial oocyte activation may improve embryo quality in older patients with diminished ovarian reserve undergoing IVF-ICSI cycles.Journal of ovarian research · 2022Article
- Molecular Clues to Understanding Causes of Human-Assisted Reproduction Treatment Failures and Possible Treatment Options.International journal of molecular sciences · 2022Review
- Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study.Journal of assisted reproduction and genetics · 2022Article
- In vitro modeling of liver fibrosis in 3D microtissues using scalable micropatterning system.Archives of toxicology · 2022Article
- Effect of A23187 ionophore treatment on human blastocyst development-a sibling oocyte study.Journal of assisted reproduction and genetics · 2022Article
- Healthy birth in a case of total globozoospermia after intracytoplasmic sperm injection and assisted oocyte activation.Romanian journal of morphology and embryology = Revue roumaine de morphologie et embryologieArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This study aimed to evaluate the efficacy and safety of calcium ionophore during assisted oocyte activation (AOA). This meta-analysis contained randomized controlled trials and prospective observational and retrospective trials. The summary odds ratio (OR) with 95% confidence intervals (CIs) was calculated for clinical pregnancy rate and live birth rate. Both fixed and random effects models were applied. A total of 22 studies were included into this meta-analysis. Seventeen of the included studies showed that calcium ionophore increased the clinical pregnancy rate (OR, 2.14; 95% CI, 1.38-3.31). Similarly, 14 studies indicated that AOA with calcium ionophore during intracytoplasmic sperm injection (ICSI) improved the live birth rate considerably (OR, 2.65; 95% CI, 1.53-4.60). Moreover, fertilization, blastocyst formation, and implantation rate were higher after using AOA with calcium ionophore combined with ICSI. In addition, calcium ionophore did not increase top-quality embryo rate, cleavage rate, miscarriage rate, congenital birth defects, and neonatal sex ratio. Therefore, calcium ionophore followed by ICSI not only significantly improved live birth and overall pregnancy, but also did not affect the incidence of miscarriage, congenital birth defects, and neonatal sex ratio. This meta-analysis indicated that using calcium ionophore to activate oocytes was beneficial for couples with poor fertilization rates following ICSI.
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